Evaluation of Dermal Wound Healing Potential: Phytochemical Characterization, Anti-inflammatory, Antioxidant, and Antimicrobial Activities of Euphorbia guyoniana Boiss. & Reut. Latex.

IF 2.3 3区化学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Chemistry & Biodiversity Pub Date : 2024-11-04 DOI:10.1002/cbdv.202402284

Khaoula Segueni, Atef Chouikh, Salah Eddine Laouini, Abderrhmane Bouafia, Mohammed Laid Tlili, Ibtissam Laib, Ouafa Boudebia, Yahia Khelef Khelef, Mahmood M S Abdullah, Johar Amin Ahmed Abdullah, Talha Bin Emran

{"title":"Evaluation of Dermal Wound Healing Potential: Phytochemical Characterization, Anti-inflammatory, Antioxidant, and Antimicrobial Activities of Euphorbia guyoniana Boiss. & Reut. Latex.","authors":"Khaoula Segueni, Atef Chouikh, Salah Eddine Laouini, Abderrhmane Bouafia, Mohammed Laid Tlili, Ibtissam Laib, Ouafa Boudebia, Yahia Khelef Khelef, Mahmood M S Abdullah, Johar Amin Ahmed Abdullah, Talha Bin Emran","doi":"10.1002/cbdv.202402284","DOIUrl":null,"url":null,"abstract":"<p><p>This study investigates the wound-healing potential of Euphorbia guyoniana latex (EGL) in male Wistar rats, along with its biochemical composition and biological activities. Phytochemical analysis identified moderate levels of phenolics, flavonoids, and tannins, with HPLC revealing five phenolic compounds. EGL demonstrated strong antioxidant activity in DPPH assays, surpassing ascorbic acid in protecting red blood cells. Its performance in the ß-carotene-linoleic acid assay was robust, though its FRAP assay results were weaker. EGL also exhibited significant anti-inflammatory activity, comparable to Acetylsalicylic acid, and showed antibacterial effects against Listeria innocua. In Vivo, EGL-infused ointments accelerated wound healing, reducing epithelialization periods to 12-16 days, with a higher wound contraction rate compared to controls. The study concludes that EGL, rich in bioactive compounds, holds potential as a promising natural agent for wound healing, owing to its potent antioxidant, anti-inflammatory, and antibacterial properties.</p>","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":null,"pages":null},"PeriodicalIF":2.3000,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chemistry & Biodiversity","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1002/cbdv.202402284","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

This study investigates the wound-healing potential of Euphorbia guyoniana latex (EGL) in male Wistar rats, along with its biochemical composition and biological activities. Phytochemical analysis identified moderate levels of phenolics, flavonoids, and tannins, with HPLC revealing five phenolic compounds. EGL demonstrated strong antioxidant activity in DPPH assays, surpassing ascorbic acid in protecting red blood cells. Its performance in the ß-carotene-linoleic acid assay was robust, though its FRAP assay results were weaker. EGL also exhibited significant anti-inflammatory activity, comparable to Acetylsalicylic acid, and showed antibacterial effects against Listeria innocua. In Vivo, EGL-infused ointments accelerated wound healing, reducing epithelialization periods to 12-16 days, with a higher wound contraction rate compared to controls. The study concludes that EGL, rich in bioactive compounds, holds potential as a promising natural agent for wound healing, owing to its potent antioxidant, anti-inflammatory, and antibacterial properties.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

皮肤伤口愈合潜力评估：Euphorbia guyoniana Boiss.乳汁。

本研究调查了雄性 Wistar 大鼠伤口愈合的潜力及其生化成分和生物活性。植物化学分析确定了中等含量的酚类、类黄酮和单宁酸，高效液相色谱分析发现了五种酚类化合物。在 DPPH 试验中，EGL 表现出很强的抗氧化活性，在保护红细胞方面超过了抗坏血酸。它在ß-胡萝卜素-亚油酸检测中的表现也很强劲，但在 FRAP 检测中的结果较弱。EGL 还具有明显的抗炎活性，可与乙酰水杨酸媲美，并对无毒李斯特菌有抗菌作用。在体内，注入 EGL 的软膏可加速伤口愈合，将上皮化时间缩短至 12-16 天，与对照组相比，伤口收缩率更高。研究得出结论：EGL富含生物活性化合物，具有强大的抗氧化、消炎和抗菌特性，有望成为促进伤口愈合的天然药物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Chemistry & Biodiversity 环境科学-化学综合

CiteScore

3.40

自引率

10.30%

发文量

475

审稿时长

2.6 months

期刊介绍： Chemistry & Biodiversity serves as a high-quality publishing forum covering a wide range of biorelevant topics for a truly international audience. This journal publishes both field-specific and interdisciplinary contributions on all aspects of biologically relevant chemistry research in the form of full-length original papers, short communications, invited reviews, and commentaries. It covers all research fields straddling the border between the chemical and biological sciences, with the ultimate goal of broadening our understanding of how nature works at a molecular level. Since 2017, Chemistry & Biodiversity is published in an online-only format.