Different patterns of longitudinal changes in antinuclear antibodies titers in children with systemic lupus erythematosus and Sjögren's syndrome.

IF 1.9 4区 医学 Q3 RHEUMATOLOGY Lupus Pub Date : 2024-11-04 DOI:10.1177/09612033241298729
Patricia Morán Álvarez, Claudia Bracaglia, Rebecca Nicolai, Luigi Giovannelli, Ivan Caiello, Alessandra Boni, Valentina Matteo, Gian Marco Moneta, Virginia Messia, Fabrizio De Benedetti, Emiliano Marasco
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Abstract

Objective: to investigate the trend of autoantibody titers during a 2-year follow-up in pediatric systemic lupus erythematosus (pSLE) and pediatric Sjögren's syndrome (pSS).

Methods: Autoantibodies testing was performed every 3-4 months during 2 years from disease onset in a cohort of children with pSLE and pSS.

Results: We enrolled 21 children with pSLE and 22 children with pSS. All pSLE patients at 2 years showed ANA titers significantly lower compared to disease onset. Eleven patients (73%) were still ANA positive at 2 years, while 4 (26%) became ANA negative. At diagnosis, 12 (80%) patients showed a homogeneous pattern, while 3 (20%) patients showed a speckled pattern. The latter remained ANA positive with the same pattern; only 2 patients with a homogenous pattern converted to speckled, 4 patients with a homogeneous pattern became ANA negative. ANA negative pSLE patients showed lower levels of interferon score compared to ANA positive patients. Anti-dsDNA titers declined equally in the two groups. All patients with pSS, at disease onset, were ANA and anti-Ro positive and 14 (66%) were anti-La positive. After 2 years of follow-up, 100% remained ANA positive but showed significant lower titers. During follow-up anti-Ro and anti-La titers remained stable.

Conclusion: different patterns in changes of ANA and ENA titers in pSLE and pSS were shown. At 2 years of follow-up, all pSLE patients had a lower ANA titer and 26% became negative; however, all pSS patients remained both ANA and ENA positive. This evidence may be due to different pathogenetic pathways in SLE and pSS.

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系统性红斑狼疮和斯约格伦综合征患儿抗核抗体滴度的不同纵向变化模式。
目的:研究小儿系统性红斑狼疮(pSLE)和小儿斯约格伦综合征(pSS)患者在两年随访期间自身抗体滴度的变化趋势:方法:在一组患有系统性红斑狼疮和小儿斯约格伦综合征的儿童中,自发病起的两年内每3-4个月进行一次自身抗体检测:结果:我们共招募了21名儿童系统性红斑狼疮患者和22名儿童系统性红斑狼疮患者。所有 pSLE 患者在 2 年后的 ANA 滴度均明显低于发病时的水平。11名患者(73%)2年后ANA仍呈阳性,4名患者(26%)ANA呈阴性。确诊时,12 名患者(80%)呈现均一模式,3 名患者(20%)呈现斑点模式。后者以相同的模式保持 ANA 阳性;只有 2 名均一模式的患者转为斑点模式,4 名均一模式的患者转为 ANA 阴性。与 ANA 阳性患者相比,ANA 阴性 pSLE 患者的干扰素评分水平较低。两组患者的抗dsDNA滴度下降幅度相同。所有 pSS 患者在发病时均为 ANA 和抗 Ro 阳性,14 人(66%)为抗 La 阳性。随访 2 年后,100% 的患者仍为 ANA 阳性,但滴度明显降低。结论:在 pSLE 和 pSS 中,ANA 和 ENA 滴度的变化呈现出不同的模式。随访2年后,所有系统性红斑狼疮患者的ANA滴度均有所下降,26%的患者转为阴性;然而,所有系统性红斑狼疮患者的ANA和ENA仍为阳性。这一证据可能是由于系统性红斑狼疮和 pSS 的致病途径不同所致。
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来源期刊
Lupus
Lupus 医学-风湿病学
CiteScore
4.20
自引率
11.50%
发文量
225
审稿时长
1 months
期刊介绍: The only fully peer reviewed international journal devoted exclusively to lupus (and related disease) research. Lupus includes the most promising new clinical and laboratory-based studies from leading specialists in all lupus-related disciplines. Invaluable reading, with extended coverage, lupus-related disciplines include: Rheumatology, Dermatology, Immunology, Obstetrics, Psychiatry and Cardiovascular Research…
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