Platelet-to-albumin ratio is an independent predictor for ventricular aneurysm formation in ST segment elevation myocardial infarction.

IF 1.5 4区医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS Coronary artery disease Pub Date : 2024-11-04 DOI:10.1097/MCA.0000000000001445

Haifeng Ding, Rui Chai, Yin Yin, Wenwen Li, Shijiu Jiang

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Abstract

Background: Left ventricular aneurysm (LVA) is a common complication of acute myocardial infarction. We aimed to investigate the association of the platelet-to-albumin ratio (PAR) with LVA formation in patients with acute ST segment elevation myocardial infarction (STEMI) who underwent primary percutaneous coronary intervention (PCI).

Methods: A total of 767 consecutive patients with STEMI were prospectively enrolled. Logistic regression analysis and restricted cubic spline (RCS) were used to assess the association between PAR and LVA formation. The predictive ability of PAR and combined variable for LVA formation were assessed using receiver-operating characteristic (ROC) curve.

Results: The prevalence of LVA was 14.1%. Univariable logistic regression analysis revealed that PAR was associated with the risk of LVA at both 1 month [odds ratio (OR) = 4.42, P < 0.001] and 6 months (OR = 4.35, P < 0.001) of follow-up. The predictive value of PAR remained significant even after multivariate logistic regression analysis at 1 month (OR = 3.42, P = 0.004) and 6 months (OR = 4.28, P < 0.001). RCS analysis revealed a nonlinear association between a higher PAR and an increased risk of LVA (nonlinear P < 0.05). In addition, the predictive abilities of PAR for LVA were 0.659. The combination of PAR, hemoglobin, left ventricular ejection fraction, and the use of angiotensin-converting enzym inhibitor/angiotensin receptor blocker significantly enhanced the ability to predict LVA formation (C statistic= 0.887).

Conclusion: A higher PAR was significantly associated with an increased risk of LVA formation in patients with acute STEMI who underwent primary PCI.

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血小板与白蛋白比值是 ST 段抬高型心肌梗死患者心室动脉瘤形成的独立预测指标。

背景：左心室动脉瘤（LVA）是急性心肌梗死的常见并发症。我们旨在研究接受初级经皮冠状动脉介入治疗（PCI）的急性 ST 段抬高型心肌梗死（STEMI）患者的血小板白蛋白比值（PAR）与 LVA 形成的关系：共有 767 名连续的 STEMI 患者接受了前瞻性研究。采用逻辑回归分析和限制性立方样条曲线（RCS）评估PAR和LVA形成之间的关系。使用接收器操作特征曲线（ROC）评估了PAR和综合变量对LVA形成的预测能力：结果：LVA的发病率为14.1%。单变量逻辑回归分析显示，PAR 与随访 1 个月[比值比 (OR) = 4.42，P < 0.001]和 6 个月[比值比 (OR) = 4.35，P < 0.001]的 LVA 风险相关。即使在 1 个月（OR = 3.42，P = 0.004）和 6 个月（OR = 4.28，P < 0.001）进行多变量逻辑回归分析后，PAR 的预测价值仍然显著。RCS 分析显示，PAR 越高，LVA 风险越高（非线性 P <0.05）。此外，PAR 对 LVA 的预测能力为 0.659。PAR、血红蛋白、左心室射血分数和血管紧张素转换酶抑制剂/血管紧张素受体阻滞剂的联合使用显著提高了预测LVA形成的能力（C统计量= 0.887）：结论：在接受初级PCI的急性STEMI患者中，PAR越高，LVA形成的风险越高。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Coronary artery disease 医学-外周血管病

CiteScore

2.50

自引率

0.00%

发文量

190

审稿时长

6-12 weeks

期刊介绍： Coronary Artery Disease welcomes reports of original research with a clinical emphasis, including observational studies, clinical trials, translational research, novel imaging, pharmacology and interventional approaches as well as advances in laboratory research that contribute to the understanding of coronary artery disease. Each issue of Coronary Artery Disease is divided into four areas of focus: Original Research articles, Review in Depth articles by leading experts in the field, Editorials and Images in Coronary Artery Disease. The Editorials will comment on selected original research published in each issue of Coronary Artery Disease, as well as highlight controversies in coronary artery disease understanding and management. Submitted artcles undergo a preliminary review by the editor. Some articles may be returned to authors without further consideration. Those being considered for publication will undergo further assessment and peer-review by the editors and those invited to do so from a reviewer pool.