Adenoid glioblastoma: Stromal hypovascularity and secretion of chondromodulin-I by tumor cells.

IF 1.3 4区 医学 Q4 CLINICAL NEUROLOGY Neuropathology Pub Date : 2024-11-03 DOI:10.1111/neup.13010
Masayuki Shintaku, Tetsuo Hashiba, Masahiro Nonaka, Akio Asai, Koji Tsuta
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Abstract

The case of a 75-year-old man with a glioblastoma of the right frontal lobe showing features of adenoid glioblastoma is reported. The tumor consisted of two components: the adenoid component, in which large, cohesive, polygonal cells with vesicular nuclei and abundant basophilic cytoplasm showed nest-like, trabecular, or tubular growth on the myxoid matrix and formed a multinodular configuration; and the subsidiary component, in which short spindle cells showed compact fascicular growth. The features of ordinary glioblastoma were also found in a small area. Tumor cells were immunoreactive for S-100 protein, glial fibrillary acidic protein, and Olig2, and some tumor cells in the adenoid component showed immunoreactivity for cytokeratins and E-cadherin. A marked regional decrease in microvascular density, approaching almost complete absence of microvessels, was demonstrated in the adenoid component. In contrast, microvascular density was well preserved in the spindle cell component and the area of ordinary glioblastoma. Tumor cells in the adenoid component showed cytoplasmic expression of chondromodulin-I, one of the cytokines that strongly inhibit angiogenesis, whereas the expression of this protein was very weak or only faint in the spindle cell component and the area of ordinary glioblastoma. A marked regional decrease in microvascular density was associated with myxoid change of the stroma and considered to be caused by the secretion of chondromodulin-I by tumor cells. Stromal hypovascularity with myxoid change might play an important role in the morphogenesis of adenoid features.

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腺胶质母细胞瘤:基质血管过少和肿瘤细胞分泌软骨素-I。
本病例报告了一名 75 岁男性的右额叶胶质母细胞瘤病例,该病例显示出腺样胶质母细胞瘤的特征。该肿瘤由两部分组成:腺样部分,其中大而内聚的多角形细胞,具有水泡状核和丰富的嗜碱性胞质,在类肌基质上呈巢状、小梁状或管状生长,并形成多结节结构;附属部分,其中短小的纺锤形细胞呈紧密的束状生长。在一小块区域还发现了普通胶质母细胞瘤的特征。肿瘤细胞对 S-100 蛋白、胶质纤维酸性蛋白和 Olig2 具有免疫活性,腺样成分中的一些肿瘤细胞对细胞角蛋白和 E-cadherin 具有免疫活性。腺样体部分的微血管密度明显下降,几乎完全没有微血管。相比之下,纺锤细胞成分和普通胶质母细胞瘤区域的微血管密度保存完好。腺样成分中的肿瘤细胞胞质表达软骨素-I,这是强烈抑制血管生成的细胞因子之一,而在纺锤体细胞成分和普通胶质母细胞瘤区域,这种蛋白的表达非常微弱或仅有微弱表达。区域性微血管密度明显降低与基质的肌样改变有关,被认为是肿瘤细胞分泌软骨素-I所致。基质血管减少伴肌瘤样改变可能在腺样体特征的形态形成中起重要作用。
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来源期刊
Neuropathology
Neuropathology 医学-病理学
CiteScore
4.10
自引率
4.30%
发文量
105
审稿时长
6-12 weeks
期刊介绍: Neuropathology is an international journal sponsored by the Japanese Society of Neuropathology and publishes peer-reviewed original papers dealing with all aspects of human and experimental neuropathology and related fields of research. The Journal aims to promote the international exchange of results and encourages authors from all countries to submit papers in the following categories: Original Articles, Case Reports, Short Communications, Occasional Reviews, Editorials and Letters to the Editor. All articles are peer-reviewed by at least two researchers expert in the field of the submitted paper.
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