Development of therapeutic and cosmetic cream based on flavonoids

IF 2.5 3区医学 Q3 CHEMISTRY, MEDICINAL Fitoterapia Pub Date : 2024-11-01 DOI:10.1016/j.fitote.2024.106283

S.M. Adekenov, D.L. Savchenko, A.O. Kenzhebekov, A.N. Zhabaeva, A.S. Adekenova, V.V. Polyakov

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Abstract

The article discusses the results of the development of a cream based on Populus balsamifera L. bud flavonoids, which have anti-inflammatory, skin-regenerating effects.

A cream's anti-inflammatory and wound-healing activity based on a flavonoid substance has been studied. In an experiment on a model of an cut skin wound, it was determined that a cream based on the sum of flavonoids of Populus balsamifera L. buds, containing pinostrobin, pinocembrin, tectochrysin, exhibits anti-inflammatory and wound-healing activity. Considering that the effectiveness of local wound treatment mainly depends on the rational treatment of the first phase of the wound process, we have developed a 1 % flavonoid cream and its production technology.

The technology for the production of flavonoid cream includes extraction and isolation of the sum of flavonoids from the raw material of Populus balsamifera L. buds, preparation of flavonoid substance and excipients, preparation of the cream base and cream, packaging and labelling of cream. Based on the results of our experiments, a pilot industrial regulation for the production of a new cream based on the sum of flavonoids of Populus balsamifera L. buds has been developed, and pilot production of an original therapeutic and cosmetic cream was organised.

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开发基于黄酮类化合物的药用和美容膏霜。

文章讨论了基于具有消炎和皮肤再生作用的杨梅花蕾类黄酮的面霜的开发成果。研究了一种基于黄酮类物质的药膏的消炎和伤口愈合活性。在一个皮肤切口模型实验中，确定了一种基于苦杨树花蕾中黄酮类物质总和的药膏，其中含有pinostrobin、pinocembrin和tectochrysin，具有消炎和伤口愈合活性。考虑到局部伤口治疗的效果主要取决于伤口第一阶段的合理治疗，我们开发了一种 1 % 的类黄酮乳膏及其生产技术。类黄酮乳膏的生产技术包括从杨树花蕾原料中提取和分离类黄酮总和、制备类黄酮物质和辅料、制备乳膏基质和乳膏、乳膏的包装和标签。根据我们的实验结果，制定了基于杨树花蕾类黄酮总和生产新型膏霜的试验性工业规程，并组织了原创药用化妆品膏霜的试验性生产。

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来源期刊

Fitoterapia 医学-药学

CiteScore

5.80

自引率

2.90%

发文量

198

审稿时长

1.5 months

期刊介绍： Fitoterapia is a Journal dedicated to medicinal plants and to bioactive natural products of plant origin. It publishes original contributions in seven major areas: 1. Characterization of active ingredients of medicinal plants 2. Development of standardization method for bioactive plant extracts and natural products 3. Identification of bioactivity in plant extracts 4. Identification of targets and mechanism of activity of plant extracts 5. Production and genomic characterization of medicinal plants biomass 6. Chemistry and biochemistry of bioactive natural products of plant origin 7. Critical reviews of the historical, clinical and legal status of medicinal plants, and accounts on topical issues.