EEG oscillations in recent suicide attempters: Assessing responses to positive and negative future imagination tasks

Abstract

Background

Our goal is to uncover Electroencephalography (EEG) power spectrum patterns during imagination tasks in individuals who attempted suicide within the past 1–4 weeks, addressing gaps in understanding the neural correlates of future imagination in suicidal behavior.

Methods

This case-control study comprised a total of 60 participants, consisting of 47 females and 13 males. The sample comprised three groups: Attempted Suicide + Major Depressive Disorder (SA+MDD), Major Depressive Disorder (MDD), and Healthy Controls (HC). To assess participants' future imagination, a unique approach called the Positive and Negative Future Imagination Task was designed, which involved scenario visualization concurrent with EEG recording. Statistical analyses included ANOVA with post-hoc pairwise comparisons to compare EEG power spectrum between three groups.

Results

It was observed that the SA+MDD group experienced significantly increased theta frequency band in the right frontocentral regions when compared to the MDD group during both positive and negative imagination tasks (P-value < 0.05). Furthermore, increased gamma activity was observed in the SA+MDD group compared to the HC group, predominantly in the right frontocentral areas during both imagination tasks.

Conclusion

The results of this study indicate that individuals who have recently attempted suicide exhibit heightened neural activity in the frontocentral regions of the right hemisphere of the brain, specifically in theta and gamma band frequencies, when contemplating both positive and negative aspects of the future. These findings, in the context of behavioral tasks may indicate a decrease in the ability to envision a positive future and an increase in visualizing a negative future.