The association among cancer-antigen-125 and pre-eclampsia and estimated fetal weight: A case-control study.

IF 1.6 Q3 OBSTETRICS & GYNECOLOGY International Journal of Reproductive Biomedicine Pub Date : 2024-10-14 eCollection Date: 2024-08-01 DOI:10.18502/ijrm.v22i8.17238
Hamideh Gholami, Lida Garrosi, Shabnam Tofighi, Zahra Ghadimi
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Abstract

Background: Although an optimal screening model is still under investigation, pre-eclampsia is a leading cause of perinatal morbidity. The association between cancer-antigen-125 (CA-125) and pre-eclampsia has been discussed in several studies recently.

Objective: We aimed to determine the association between CA-125 and preeclampsia and estimated fetal weight.

Materials and methods: This case-control study was performed on 30 pregnant women with pre-eclampsia who were homogenized in terms of age, body mass index, and gestational age with 30 normal pregnant women. Participants were recruited via convenience sampling. The level of CA-125 in blood at the time of termination of pregnancy was measured by Enzyme Linked Immunosorbent Assay. The urine sample was used to check proteinuria. Blood pressure and pregnancy outcomes were assessed and recorded.

Results: The mean serum CA-125 level in study group was considerably higher than control group (p < 0.001). Elevating the level of CA-125 has increased the likelihood of pre-eclampsia by 1.5 times. A significant direct correlation was obtained between CA-125 level and the amount of urinary protein (r = 0.605, p < 0.001). Also, a significant but negative correlation was obtained between the CA-125 level and the estimated weight of the fetus (r = -0.593, p < 0.001).

Conclusion: Increasing the serum level of CA-125 with high sensitivity and specificity is significantly associated with the occurrence of pre-eclampsia and estimated fetal weight.

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癌症抗原-125 与先兆子痫和估计胎儿体重之间的关系:病例对照研究
背景:尽管最佳筛查模式仍在研究中,但先兆子痫是围产期发病率的主要原因。最近有几项研究讨论了癌抗原-125(CA-125)与先兆子痫之间的关系:我们旨在确定 CA-125 与先兆子痫和估计胎儿体重之间的关系:这项病例对照研究的对象是30名患有先兆子痫的孕妇,她们在年龄、体重指数和胎龄方面与30名正常孕妇相同。研究人员是通过方便抽样的方式招募的。终止妊娠时血液中的 CA-125 含量是通过酶联免疫吸附试验测定的。尿液样本用于检查蛋白尿。对血压和妊娠结果进行了评估和记录:研究组的平均血清 CA-125 水平明显高于对照组(P 0.001)。CA-125 水平升高会使先兆子痫的可能性增加 1.5 倍。CA-125 水平与尿蛋白量之间存在明显的直接相关性(r = 0.605,p 0.001)。此外,CA-125 水平与胎儿的估计体重(r = -0.593,P 0.001)之间存在明显的负相关:结论:CA-125血清水平的升高与先兆子痫的发生和估计的胎儿体重密切相关,其敏感性和特异性都很高。
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来源期刊
CiteScore
2.40
自引率
7.70%
发文量
93
审稿时长
16 weeks
期刊介绍: The International Journal of Reproductive BioMedicine (IJRM), formerly published as "Iranian Journal of Reproductive Medicine (ISSN: 1680-6433)", is an international monthly scientific journal for who treat and investigate problems of infertility and human reproductive disorders. This journal accepts Original Papers, Review Articles, Short Communications, Case Reports, Photo Clinics, and Letters to the Editor in the fields of fertility and infertility, ethical and social issues of assisted reproductive technologies, cellular and molecular biology of reproduction including the development of gametes and early embryos, assisted reproductive technologies in model system and in a clinical environment, reproductive endocrinology, andrology, epidemiology, pathology, genetics, oncology, surgery, psychology, and physiology. Emerging topics including cloning and stem cells are encouraged.
期刊最新文献
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