AIMP1-Derived Peptide Secreted from Hair Follicle Stem Cells Promotes Hair Growth by Activating Dermal Papilla Cells.

IF 8.2 2区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY International Journal of Biological Sciences Pub Date : 2024-10-21 eCollection Date: 2024-01-01 DOI:10.7150/ijbs.101127
YounHa Kim, Sang Bum Kim, Ho Lee, Doyeun Kim, Soon Sun Bak, Ina Yoon, Seongmin Cho, Seung Jae Jeong, Yoon Jeon, Jina Kim, Ji-Hee Kim, Soohwan Oh, Khas-Erdene Battogtokh, Min Chul Park, Young Kwan Sung, Sunghoon Kim
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Abstract

Hair follicle stem cells (HFSCs) and dermal papilla cells (DPCs) are crucial in the biogenesis and maintenance of hair follicles (HFs). This study demonstrated that a fragment derived from aminoacyl-tRNA synthetase-interacting multifunctional protein1 (AIMP1) secreted from HFSCs activated DPCs and maintained HF homeostasis. A histological analysis revealed that AIMP1 levels in HF decreased with hair loss. Hair regrowth in AIMP1-induced mice was faster than in non-induced mice. Deletion mapping revealed 41 amino acids (TN41, aa 6-46) as the active region of AIMP1. The N-terminal peptide fragment of AIMP1 generated by MMP1 was secreted from Wnt-treated HFSCs to activate DPCs. TN41 activated Akt and ERK, increased β-catenin, and enhanced DPC activation. TN41 promoted hair shaft elongation in cultured human HFs and improved the hair-inducing activity of cultured DPC spheroids. Our findings suggest that the AIMP1 fragment secreted from HFSCs stimulates active hair regrowth through activating DPCs.

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毛囊干细胞分泌的 AIMP1 衍生肽通过激活真皮乳头细胞促进毛发生长
毛囊干细胞(HFSCs)和真皮乳头细胞(DPCs)对毛囊(HFs)的生物生成和维持至关重要。这项研究证明,从毛囊干细胞分泌的氨基酰-tRNA合成酶-相互作用多功能蛋白1(AIMP1)中提取的片段能激活真皮乳头细胞,维持毛囊的平衡。组织学分析表明,HF 中的 AIMP1 水平随着脱发而降低。AIMP1诱导小鼠的毛发再生速度快于非诱导小鼠。缺失图谱显示 41 个氨基酸(TN41,aa 6-46)是 AIMP1 的活性区。由 MMP1 生成的 AIMP1 N 端多肽片段从 Wnt 处理的高频间充质干细胞中分泌出来,激活 DPCs。TN41 激活了 Akt 和 ERK,增加了 β-catenin,并增强了 DPC 的激活。TN41 可促进培养的人类 HF 的毛干伸长,并提高培养的 DPC 球体的毛发诱导活性。我们的研究结果表明,高频间充质干细胞分泌的 AIMP1 片段可通过激活 DPC 刺激毛发再生。
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来源期刊
International Journal of Biological Sciences
International Journal of Biological Sciences 生物-生化与分子生物学
CiteScore
16.90
自引率
1.10%
发文量
413
审稿时长
1 months
期刊介绍: The International Journal of Biological Sciences is a peer-reviewed, open-access scientific journal published by Ivyspring International Publisher. It dedicates itself to publishing original articles, reviews, and short research communications across all domains of biological sciences.
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