Engineering Probiotics for Diabetes Management: Advances, Challenges, and Future Directions in Translational Microbiology.

IF 6.6 2区 医学 Q1 NANOSCIENCE & NANOTECHNOLOGY International Journal of Nanomedicine Pub Date : 2024-10-28 eCollection Date: 2024-01-01 DOI:10.2147/IJN.S492651
Shenghao Zhang, Jiahui Ma, Yilei Ma, Jia Yi, Beier Wang, Hanbing Wang, Qinsi Yang, Kun Zhang, Xiaoqing Yan, Da Sun, Jinfeng You
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Abstract

Background: Diabetes Mellitus (DM) is a substantial health concern worldwide, and its incidence is progressively escalating. Conventional pharmacological interventions frequently entail undesirable side effects, and while probiotics offer benefits, they are hindered by constraints such as diminished stability and effectiveness within the gastrointestinal milieu. Given these complications, the advent of bioengineered probiotics is a promising alternative for DM management.

Aim of review: The objective of this review is to provide an exhaustive synthesis of the most recent studies on the use of engineered probiotics in the management of DM. This study aimed to clarify the mechanisms through which these probiotics function, evaluate their clinical effectiveness, and enhance public awareness of their prospective advantages in the treatment of DM.

Key scientific concepts of review: Scholarly critiques have explored diverse methodologies of probiotic engineering, including physical alteration, bioenrichment, and genetic manipulation. These techniques augment the therapeutic potency of probiotics by ameliorating gut microbiota, fortifying the intestinal barrier, modulating metabolic pathways, and regulating immune responses. Such advancements have established engineered probiotics as a credible therapeutic strategy for DM, potentially providing enhanced results compared to conventional treatments.

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用于糖尿病管理的工程益生菌:转化微生物学的进展、挑战和未来方向》。
背景:糖尿病(DM)是全球关注的重大健康问题,其发病率正在逐步上升。传统的药物干预往往会产生不良副作用,而益生菌虽然能带来益处,但却受到胃肠道环境稳定性和有效性降低等制约因素的影响。鉴于这些并发症,生物工程益生菌的出现为糖尿病管理提供了一种前景广阔的替代方案:本综述旨在详尽综述有关使用工程益生菌治疗 DM 的最新研究。本研究旨在阐明这些益生菌发挥作用的机制,评估其临床疗效,并提高公众对其治疗DM的潜在优势的认识:学术评论探讨了益生菌工程的各种方法,包括物理改变、生物富集和遗传操作。这些技术通过改善肠道微生物群、强化肠道屏障、调节代谢途径和调节免疫反应来增强益生菌的治疗效力。这些进展已将工程益生菌确立为一种治疗糖尿病的可靠策略,与传统治疗方法相比,它有可能提供更好的效果。
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来源期刊
International Journal of Nanomedicine
International Journal of Nanomedicine NANOSCIENCE & NANOTECHNOLOGY-PHARMACOLOGY & PHARMACY
CiteScore
14.40
自引率
3.80%
发文量
511
审稿时长
1.4 months
期刊介绍: The International Journal of Nanomedicine is a globally recognized journal that focuses on the applications of nanotechnology in the biomedical field. It is a peer-reviewed and open-access publication that covers diverse aspects of this rapidly evolving research area. With its strong emphasis on the clinical potential of nanoparticles in disease diagnostics, prevention, and treatment, the journal aims to showcase cutting-edge research and development in the field. Starting from now, the International Journal of Nanomedicine will not accept meta-analyses for publication.
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