Oxygen-generating hydrogels combined with electrical stimulation: A dual approach for promoting diabetic wound healing

IF 9.4 1区 医学 Q1 ENGINEERING, BIOMEDICAL Acta Biomaterialia Pub Date : 2024-12-01 DOI:10.1016/j.actbio.2024.10.049
Taishan Liu , Linlin Qu , Chenhui Zhu , Mengdi Guo , Xiaoxuan Ma , Huan Lei , Daidi Fan
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Abstract

Chronic wounds resulting from hyperglycemia and hypoxia are common complications in diabetic patients, posing significant challenges for clinical treatment. In this study, we developed a hydrogel (PVNP-SP) using [VBIM]Br, NIPAM, PEGDA, and spirulina, which exhibited strong antioxidant properties. The incorporation of [VBIM]Br endowed the hydrogel with electrical conductivity, allowing it to activate voltage-gated ion channels under an external electric field, thereby promoting cell survival and migration. The hydrogel also enhanced cellular antioxidant capacity by providing sustained oxygenation, inhibiting HIF-1α nuclear translocation, and activating the Nrf2/HO-1 pathway. Notably, in a chronic wound model, the combined effects of oxygen production and electrical stimulation from the PVNP-SP hydrogel significantly reduced wound inflammation, promoted collagen deposition and angiogenesis, and facilitated early wound closure. This therapeutic strategy, which mitigates hypoxia while integrating electrical stimulation, offers a highly effective strategy for improving chronic wound healing in diabetic patients.

Statement of significance

Inspired by photoautotrophic organisms, we combined microalgae with a conductive hydrogel and we demonstrated the synergistic promotion of chronic wound healing by electrical stimulation combined with microalgae oxygen-producing hydrogel. The approach of combining microalgae hydrogel patches with electrical stimulation demonstrates the feasibility of delivering oxygen to tissues while combining electrical stimulation for synergistic tissue repair. The hydrogel is easy to fabricate and handle, and may be suitable for a variety of treatments, such as myocardial infarction, lower limb ischemia, and drug delivery. The potential applicability of this hydrogel in a variety of treatments suggests that it has promising applications in regenerative medicine.

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制氧水凝胶与电刺激相结合:促进糖尿病伤口愈合的双重方法。
高血糖和缺氧导致的慢性伤口是糖尿病患者常见的并发症,给临床治疗带来了巨大挑战。在这项研究中,我们利用[VBIM]Br、NIPAM、PEGDA 和螺旋藻开发了一种水凝胶(PVNP-SP),它具有很强的抗氧化性。VBIM]Br 的加入赋予了水凝胶导电性,使其能够在外部电场作用下激活电压门控离子通道,从而促进细胞存活和迁移。水凝胶还通过提供持续氧合作用、抑制 HIF-1α 核转位和激活 Nrf2/HO-1 通路来增强细胞的抗氧化能力。值得注意的是,在慢性伤口模型中,PVNP-SP 水凝胶产生的氧气和电刺激的综合效应显著减轻了伤口炎症,促进了胶原沉积和血管生成,并有助于伤口的早期闭合。这种治疗策略在缓解缺氧的同时还结合了电刺激,为改善糖尿病患者的慢性伤口愈合提供了一种非常有效的策略。意义说明:受光照自养生物的启发,我们将微藻与导电水凝胶相结合,并证明了电刺激与微藻产氧水凝胶相结合可协同促进慢性伤口愈合。将微藻水凝胶贴片与电刺激相结合的方法证明了在向组织输送氧气的同时结合电刺激协同修复组织的可行性。这种水凝胶易于制造和处理,可用于心肌梗塞、下肢缺血和药物输送等多种治疗。这种水凝胶在各种治疗中的潜在适用性表明,它在再生医学中具有广阔的应用前景。
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来源期刊
Acta Biomaterialia
Acta Biomaterialia 工程技术-材料科学:生物材料
CiteScore
16.80
自引率
3.10%
发文量
776
审稿时长
30 days
期刊介绍: Acta Biomaterialia is a monthly peer-reviewed scientific journal published by Elsevier. The journal was established in January 2005. The editor-in-chief is W.R. Wagner (University of Pittsburgh). The journal covers research in biomaterials science, including the interrelationship of biomaterial structure and function from macroscale to nanoscale. Topical coverage includes biomedical and biocompatible materials.
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