Preferences and attitudes regarding early intervention in multiple sclerosis: A systematic literature review

IF 2.9 3区医学 Q2 CLINICAL NEUROLOGY Multiple sclerosis and related disorders Pub Date : 2024-10-28 DOI:10.1016/j.msard.2024.106143

Sylvia Martin , Ulrik Kihlbom , Guido Pasquini , Filippo Gerli , Claudia Niccolai , Sara Della Bella , Emilio Portaccio , Matteo Betti , Maria Pia Amato , Anat Achiron , Alon Kalron , Roy Aloni , Karin Schölin Bywall

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Abstract

Background

Multiple sclerosis (MS) is a chronic inflammatory disorder affecting the brain and spinal cord, characterized by immune-mediated myelin damage. Early intervention and detection programs have emerged as promising strategies to improve patient outcomes by identifying and treating MS in its earliest stages.

Objective

This systematic literature review aims to provide an overview of the preferences, attitudes, and opinions of both patients and healthcare professionals regarding early intervention or early detection programs for MS.

Methods

A comprehensive search strategy was employed in March 2023 across multiple databases (MEDLINE, Scopus, PsyInfo, PubMed), from 1990 to 2023. A total of 38 articles were selected for analysis based on predefined inclusion and exclusion criteria.

Results

The majority of articles were published in recent years and represented different methods from case reports to randomized controlled trials, with fewer systematic literature reviews. Data collection approaches included patients, healthcare workers, or mixed samples with varying age ranges and gender ratios, frequently preferring women. These samples represented different preference study methods. The included studies were primarily conducted in the USA and the UK. Thematic analysis revealed several key themes : 1) differences emerged between healthcare professionals' and patients' perspectives 2) interventions for MS outside Disease-Modifying Therapies (DMTs) 3) severe side effects 4) communication, information, and knowledge 5) psychological and emotional aspects.

Conclusions

Understanding these diverse factors and subgroups within the MS population can inform more effective, personalized approaches to MS prevention and treatment.

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关于多发性硬化症早期干预的偏好和态度：系统文献综述。

背景：多发性硬化症（MS）是一种影响大脑和脊髓的慢性炎症性疾病，其特点是免疫介导的髓鞘损伤。早期干预和检测计划通过在多发性硬化症的早期阶段识别和治疗多发性硬化症，已成为改善患者预后的有前途的策略：本系统性文献综述旨在概述患者和医护人员对多发性硬化症早期干预或早期检测项目的偏好、态度和意见：我们于 2023 年 3 月在多个数据库（MEDLINE、Scopus、PsyInfo、PubMed）中采用了全面的检索策略，检索期从 1990 年至 2023 年。根据预先确定的纳入和排除标准，共筛选出 38 篇文章进行分析：大多数文章都是近年来发表的，采用了从病例报告到随机对照试验等不同方法，系统性文献综述较少。数据收集方法包括患者、医护人员或混合样本，这些样本的年龄范围和性别比例各不相同，通常更倾向于女性。这些样本代表了不同的偏好研究方法。纳入的研究主要在美国和英国进行。主题分析揭示了几个关键主题：1）医护人员和患者观点之间的差异；2）疾病改变疗法（DMT）之外的多发性硬化症干预措施；3）严重的副作用；4）沟通、信息和知识；5）心理和情感方面：结论：了解多发性硬化症人群中的这些不同因素和亚群，可以为多发性硬化症的预防和治疗提供更有效、更个性化的方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Multiple sclerosis and related disorders CLINICAL NEUROLOGY-

CiteScore

5.80

自引率

20.00%

发文量

814

审稿时长

66 days

期刊介绍： Multiple Sclerosis is an area of ever expanding research and escalating publications. Multiple Sclerosis and Related Disorders is a wide ranging international journal supported by key researchers from all neuroscience domains that focus on MS and associated disease of the central nervous system. The primary aim of this new journal is the rapid publication of high quality original research in the field. Important secondary aims will be timely updates and editorials on important scientific and clinical care advances, controversies in the field, and invited opinion articles from current thought leaders on topical issues. One section of the journal will focus on teaching, written to enhance the practice of community and academic neurologists involved in the care of MS patients. Summaries of key articles written for a lay audience will be provided as an on-line resource. A team of four chief editors is supported by leading section editors who will commission and appraise original and review articles concerning: clinical neurology, neuroimaging, neuropathology, neuroepidemiology, therapeutics, genetics / transcriptomics, experimental models, neuroimmunology, biomarkers, neuropsychology, neurorehabilitation, measurement scales, teaching, neuroethics and lay communication.