Lasso peptides realm: Insights and applications

IF 2.8 4区 医学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Peptides Pub Date : 2024-11-01 DOI:10.1016/j.peptides.2024.171317
Othman Al Musaimi
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Abstract

Lasso peptides exhibit a range of bioactivities, including antiviral effects, inhibition of the glucagon receptor, blockade of the endothelin type B receptor, inhibition of myosin light chain kinase, and modulation of the atrial natriuretic factor, as well as notable antimicrobial properties. Intriguingly, lasso peptides exhibit remarkable proteolytic and thermal stability, addressing one of the key challenges that traditional peptides often face. The challenge in producing those valuable peptides remains the main hurdle in the way of producing larger quantities or even modifying them with more potent analogues. Genome mining and heterologous expression approaches have greatly facilitated the production of lasso peptides, moving beyond mere isolation techniques. This advancement not only allows for larger quantities but also enables the creation of additional analogues with improved stability and potency. This review aims to explore the unique bioactivities and stability of lasso peptides, along with recent advancements in genome mining and heterologous expression that address production challenges and open pathways for engineering potent analogues.
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拉索肽领域:洞察与应用。
拉索肽具有一系列生物活性,包括抗病毒作用、抑制胰高血糖素受体、阻断 B 型内皮素受体、抑制肌球蛋白轻链激酶、调节心房利钠因子,以及显著的抗微生物特性。有趣的是,拉索肽具有显著的蛋白水解稳定性和热稳定性,解决了传统多肽经常面临的关键挑战之一。生产这些有价值的多肽所面临的挑战仍然是生产更多甚至用更强效的类似物对其进行改良的主要障碍。基因组挖掘和异源表达方法大大促进了套索肽的生产,超越了单纯的分离技术。这一进步不仅可以生产更多数量的拉索肽,还能创造出更多具有更高稳定性和效力的类似物。
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来源期刊
Peptides
Peptides 医学-生化与分子生物学
CiteScore
6.40
自引率
6.70%
发文量
130
审稿时长
28 days
期刊介绍: Peptides is an international journal presenting original contributions on the biochemistry, physiology and pharmacology of biological active peptides, as well as their functions that relate to gastroenterology, endocrinology, and behavioral effects. Peptides emphasizes all aspects of high profile peptide research in mammals and non-mammalian vertebrates. Special consideration can be given to plants and invertebrates. Submission of articles with clinical relevance is particularly encouraged.
期刊最新文献
The Viktor Mutt Award Lecture 2024 to Thomas Hökfelt. The effects of corticotropin-releasing factor (CRF) and urocortins on the noradrenaline (NA) released from the locus coeruleus (LC). Corrigendum to "Lasso peptides realm: Insights and applications" Peptides 182(December) (2024) 171317. Host defense peptides at the crossroad of endothelial cell physiology: Insight into mechanistic and pharmacological implications Discovery of the bioactive form of glucagon-like peptide-1: An attempt to correct some misconceptions
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