Understanding the burden of weekly somatrogon injections compared with daily somatropin injections in children with growth hormone deficiency: a plain language summary of publication.
Aristides K Maniatis, Mauri Carakushansky, Sonya Galcheva, Gnanagurudasan Prakasam, Larry A Fox, Adriana Dankovcikova, Jane Loftus, Andrew A Palladino, Maria de Los Angeles Resa, Carrie Turich Taylor, Mehul T Dattani, Jan Lebl
{"title":"Understanding the burden of weekly somatrogon injections compared with daily somatropin injections in children with growth hormone deficiency: a plain language summary of publication.","authors":"Aristides K Maniatis, Mauri Carakushansky, Sonya Galcheva, Gnanagurudasan Prakasam, Larry A Fox, Adriana Dankovcikova, Jane Loftus, Andrew A Palladino, Maria de Los Angeles Resa, Carrie Turich Taylor, Mehul T Dattani, Jan Lebl","doi":"10.1177/20420188241274363","DOIUrl":null,"url":null,"abstract":"<p><p>• For children with growth <b>hormone</b> deficiency, once-weekly <b>somatrogon</b> injections were less of a burden than once-daily <b>somatropin</b> injections. • The safety of weekly <b>somatrogon</b> was similar to that of daily <b>somatropin</b>. • Compared with daily <b>somatropin</b> injections, children with growth <b>hormone</b> deficiency may be less likely to miss weekly <b>somatrogon</b> injections. ○ This is because weekly <b>somatrogon</b> injections were less of a burden and were less likely to interfere with daily activities compared with daily <b>somatropin</b> injections. The purpose of this plain language summary is to help you to understand the findings from recent research. • <b>Somatrogon</b> is used to treat the condition under study that is discussed in this summary. Approval varies by country; please check with your local provider for more details. • The results of this study may differ from those of other studies. Health professionals should make treatment decisions based on all available evidence and not on the results of a single study. <b>This original scientific article on which this summary is based was published in the <i>Journal of the Endocrine Society</i> and can be accessed for free at: https://academic.oup.com/jes/article/6/10/bvac117/6695276. The details of the original article are as follows:</b> <i>Aristides K. Maniatis, Mauri Carakushansky, Sonya Galcheva, Gnanagurudasan Prakasam, Larry A. Fox, Adriana Dankovcikova, Jane Loftus, Andrew A. Palladino, Maria de los Angeles Resa, Carrie Turich Taylor, Mehul T. Dattani, Jan Lebl</i>. Treatment burden of weekly <b>somatrogon</b> versus daily <b>somatropin</b> in children with growth <b>hormone</b> deficiency: a randomized study. <i>J Endocr Soc</i> 2022; 6(10): bvac117. DOI: 10.1210/jendso/bvac117.</p>","PeriodicalId":22998,"journal":{"name":"Therapeutic Advances in Endocrinology and Metabolism","volume":null,"pages":null},"PeriodicalIF":3.9000,"publicationDate":"2024-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11531668/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Therapeutic Advances in Endocrinology and Metabolism","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1177/20420188241274363","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}
引用次数: 0
Abstract
• For children with growth hormone deficiency, once-weekly somatrogon injections were less of a burden than once-daily somatropin injections. • The safety of weekly somatrogon was similar to that of daily somatropin. • Compared with daily somatropin injections, children with growth hormone deficiency may be less likely to miss weekly somatrogon injections. ○ This is because weekly somatrogon injections were less of a burden and were less likely to interfere with daily activities compared with daily somatropin injections. The purpose of this plain language summary is to help you to understand the findings from recent research. • Somatrogon is used to treat the condition under study that is discussed in this summary. Approval varies by country; please check with your local provider for more details. • The results of this study may differ from those of other studies. Health professionals should make treatment decisions based on all available evidence and not on the results of a single study. This original scientific article on which this summary is based was published in the Journal of the Endocrine Society and can be accessed for free at: https://academic.oup.com/jes/article/6/10/bvac117/6695276. The details of the original article are as follows:Aristides K. Maniatis, Mauri Carakushansky, Sonya Galcheva, Gnanagurudasan Prakasam, Larry A. Fox, Adriana Dankovcikova, Jane Loftus, Andrew A. Palladino, Maria de los Angeles Resa, Carrie Turich Taylor, Mehul T. Dattani, Jan Lebl. Treatment burden of weekly somatrogon versus daily somatropin in children with growth hormone deficiency: a randomized study. J Endocr Soc 2022; 6(10): bvac117. DOI: 10.1210/jendso/bvac117.
- 对于生长激素缺乏症儿童来说,每周注射一次索马曲贡比每天注射一次索马托品造成的负担要小。- 每周注射一次索马曲贡的安全性与每天注射一次索马托品的安全性相似。- 与每天注射一次索马特罗普相比,生长激素缺乏症患儿错过每周一次索马特罗普注射的可能性较小。这是因为与每天注射索马托品相比,每周注射一次索马托品的负担较轻,而且不太可能影响日常活动。这份通俗易懂的摘要旨在帮助您了解最新的研究结果。- Somatrogon用于治疗本摘要中讨论的研究中的病症。批准情况因国家而异,详情请咨询当地医疗机构。- 本研究结果可能与其他研究结果不同。医疗专业人员应根据所有可用证据而非单项研究结果做出治疗决定。本摘要所依据的原始科学文章发表在《内分泌学会杂志》(Journal of the Endocrine Society)上,可在以下网址免费获取:https://academic.oup.com/jes/article/6/10/bvac117/6695276。原文详情如下:Aristides K. Maniatis, Mauri Carakushansky, Sonya Galcheva, Gnanagurudasan Prakasam, Larry A. Fox, Adriana Dankovcikova, Jane Loftus, Andrew A. Palladino, Maria de los Angeles Resa, Carrie Turich Taylor, Mehul T. Dattani, Jan Lebl.生长激素缺乏症儿童每周使用索马特罗贡与每天使用索马特罗宾的治疗负担:一项随机研究。J Endocr Soc 2022; 6(10): bvac117.DOI: 10.1210/jendso/bvac117.
期刊介绍:
Therapeutic Advances in Endocrinology and Metabolism delivers the highest quality peer-reviewed articles, reviews, and scholarly comment on pioneering efforts and innovative studies across all areas of endocrinology and metabolism.