Medications Associated with Geriatric Syndromes and Prescribing Patterns: The Impact of Excessive Polypharmacy in Older Adult Patients.

IF 2.8 3区 医学 Q1 Pharmacology, Toxicology and Pharmaceutics Therapeutics and Clinical Risk Management Pub Date : 2024-10-29 eCollection Date: 2024-01-01 DOI:10.2147/TCRM.S493095
Ahmad Al-Azayzih, Walid Al-Qerem, Sayer Al-Azzam, Karem H Alzoubi, Feras Jirjees, Khalid Al-Kubaisi, Zelal Kharaba, Suhaib Muflih, Roaa J Kanaan, Ayah H Abandeh
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Abstract

Aims of the study: To assess the prescribing patterns of medications associated with geriatric syndromes (MAGS) in older adult patients with multiple comorbidities and to identify factors that may increase the risk of MAGS prescribing in the same population.

Methodology: This study involved a retrospective analysis of the electronic medical records of older adult patients (≥ 65 years) who visited outpatient clinics at King Abdullah University Hospital (KAUH) in Jordan between January 1, 2019, and June 1, 2024. The collected data included patient demographics, medical history, and medications, focusing on those associated with geriatric syndromes. Descriptive and logistic regression statistical analyses were performed using SPSS with the significance level set at p < 0.05.

Results: The study included 1087 older adult patients (52.7% female), with a median age of 71 years. The common conditions existed were peptic ulcer disease (57.1%), hypertension (54.65%), and uncomplicated diabetes (50%). Polypharmacy was presented in 94.8% of total patients number, with 41.6% experiencing excessive polypharmacy. Antihypertensives (78.4%), non-opioid analgesics (56.5%), and antidiabetics (51.8%) were the most frequently prescribed MAGS, which frequently resulted in falls (96%), urinary incontinence (87.6%), and depression (87.3%). Patients with excessive polypharmacy had significantly higher MAGS scores than those with moderate or mild polypharmacy (95% CI: -2.230 to -1.770 and -3.322 to -2.678, respectively, P < 0.001).

Conclusion: The findings demonstrate a high prevalence of excessive polypharmacy among older adult patients, significantly contributing to the elevated prescription level of medications associated with geriatric syndrome occurrence, particularly falls, urinary incontinence, and depression.

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与老年综合症相关的药物和处方模式:老年患者过度使用多种药物的影响》。
研究目的评估患有多种并发症的老年患者开具老年综合征(MAGS)相关药物处方的模式,并确定可能增加同一人群开具MAGS处方风险的因素:本研究对2019年1月1日至2024年6月1日期间在约旦阿卜杜拉国王大学医院(KAUH)门诊就诊的老年患者(≥65岁)的电子病历进行了回顾性分析。收集的数据包括患者的人口统计学特征、病史和用药情况,重点是与老年综合征相关的药物。使用 SPSS 进行了描述性和逻辑回归统计分析,显著性水平设定为 p <0.05:研究包括 1087 名老年患者(52.7% 为女性),中位年龄为 71 岁。常见疾病为消化性溃疡(57.1%)、高血压(54.65%)和无并发症糖尿病(50%)。在所有患者中,94.8%的人使用多种药物,41.6%的人使用过量多种药物。抗高血压药(78.4%)、非阿片类镇痛药(56.5%)和抗糖尿病药(51.8%)是最常处方的 MAGS,这些药物经常导致跌倒(96%)、尿失禁(87.6%)和抑郁(87.3%)。过度使用多种药物的患者的 MAGS 评分明显高于中度或轻度使用多种药物的患者(95% CI:分别为-2.230 至 -1.770 和-3.322 至 -2.678,P < 0.001):研究结果表明,在老年患者中,过度使用多种药物的情况非常普遍,这在很大程度上导致了与老年综合症(尤其是跌倒、尿失禁和抑郁)发生相关的药物处方水平升高。
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来源期刊
Therapeutics and Clinical Risk Management
Therapeutics and Clinical Risk Management HEALTH CARE SCIENCES & SERVICES-
CiteScore
5.30
自引率
3.60%
发文量
139
审稿时长
16 weeks
期刊介绍: Therapeutics and Clinical Risk Management is an international, peer-reviewed journal of clinical therapeutics and risk management, focusing on concise rapid reporting of clinical studies in all therapeutic areas, outcomes, safety, and programs for the effective, safe, and sustained use of medicines, therapeutic and surgical interventions in all clinical areas. The journal welcomes submissions covering original research, clinical and epidemiological studies, reviews, guidelines, expert opinion and commentary. The journal will consider case reports but only if they make a valuable and original contribution to the literature. As of 18th March 2019, Therapeutics and Clinical Risk Management will no longer consider meta-analyses for publication. The journal does not accept study protocols, animal-based or cell line-based studies.
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