{"title":"An Isoniazid-Based reversible Schiff base chemosensor for Multi-Analyte (Cu2+, Ni2+, Hg2+) detection","authors":"Manpreet Kaur , Virender , Ashwani Kumar , Santosh Kumar Dubey","doi":"10.1016/j.poly.2024.117282","DOIUrl":null,"url":null,"abstract":"<div><div>Isoniazid-based Schiff base N’-(furan-2-ylmethylene)isonicotinohydrazide (<strong>FINH</strong>) has been synthesized. <strong>FINH</strong> has proven its ability to selectively sense and respond to Cu<sup>2+</sup>, Ni<sup>2+</sup>, and Hg<sup>2+</sup>, which shows its potential as a chemosensor. UV–visible experiments, the absorption band (at 360 nm) of <strong>FINH</strong> shifted with the gradual addition of Cu<sup>2+</sup>, Ni<sup>2+</sup>, and Hg<sup>2+</sup>. A significant quenching in the emission band of <strong>FINH</strong> in fluorescence spectra has been observed with the addition of analytes at the physiological pH range. Cyclic voltammetric experiments have been conducted to determine the electron transfer process that occurs during the complexation of <strong>FINH</strong> with analytes. Moreover, the interactions of <strong>FINH</strong>-metal ions are reversible, and their reversible behavior has been demonstrated with the Na<sub>2</sub>EDTA solution. The binding insights among <strong>FINH</strong> and Cu<sup>2+</sup>, Ni<sup>2+</sup>, and Hg<sup>2+</sup> are explained by IR spectral study. Additionally, the <strong>FINH</strong> works within the appreciable detection limit of 9.472 x 10<sup>−7</sup> M (for Cu<sup>2+</sup>), 7.685 x 10<sup>−7</sup> M (for Ni<sup>2+</sup>) and 2.411 x 10<sup>−7</sup> M (for Hg<sup>2+</sup>), limit of quantitation of 3.15 x 10<sup>−6</sup> M (for Cu<sup>2+</sup>), 2.561 x 10<sup>−6</sup> M (for Ni<sup>2+</sup>) and 8.036 x 10<sup>−7</sup> M (for Hg<sup>2+</sup>). Applying this isoniazid-based reversible chemosensor in analyzing real samples demonstrates its practicality and effectiveness for multi-analyte detection. This sensor could consistently measure metal ion concentrations in various environmental and biological samples, providing a valuable tool for monitoring pollutants and evaluating exposure risks.</div></div>","PeriodicalId":20278,"journal":{"name":"Polyhedron","volume":"265 ","pages":"Article 117282"},"PeriodicalIF":2.4000,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Polyhedron","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0277538724004583","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, INORGANIC & NUCLEAR","Score":null,"Total":0}
引用次数: 0
Abstract
Isoniazid-based Schiff base N’-(furan-2-ylmethylene)isonicotinohydrazide (FINH) has been synthesized. FINH has proven its ability to selectively sense and respond to Cu2+, Ni2+, and Hg2+, which shows its potential as a chemosensor. UV–visible experiments, the absorption band (at 360 nm) of FINH shifted with the gradual addition of Cu2+, Ni2+, and Hg2+. A significant quenching in the emission band of FINH in fluorescence spectra has been observed with the addition of analytes at the physiological pH range. Cyclic voltammetric experiments have been conducted to determine the electron transfer process that occurs during the complexation of FINH with analytes. Moreover, the interactions of FINH-metal ions are reversible, and their reversible behavior has been demonstrated with the Na2EDTA solution. The binding insights among FINH and Cu2+, Ni2+, and Hg2+ are explained by IR spectral study. Additionally, the FINH works within the appreciable detection limit of 9.472 x 10−7 M (for Cu2+), 7.685 x 10−7 M (for Ni2+) and 2.411 x 10−7 M (for Hg2+), limit of quantitation of 3.15 x 10−6 M (for Cu2+), 2.561 x 10−6 M (for Ni2+) and 8.036 x 10−7 M (for Hg2+). Applying this isoniazid-based reversible chemosensor in analyzing real samples demonstrates its practicality and effectiveness for multi-analyte detection. This sensor could consistently measure metal ion concentrations in various environmental and biological samples, providing a valuable tool for monitoring pollutants and evaluating exposure risks.
期刊介绍:
Polyhedron publishes original, fundamental, experimental and theoretical work of the highest quality in all the major areas of inorganic chemistry. This includes synthetic chemistry, coordination chemistry, organometallic chemistry, bioinorganic chemistry, and solid-state and materials chemistry.
Papers should be significant pieces of work, and all new compounds must be appropriately characterized. The inclusion of single-crystal X-ray structural data is strongly encouraged, but papers reporting only the X-ray structure determination of a single compound will usually not be considered. Papers on solid-state or materials chemistry will be expected to have a significant molecular chemistry component (such as the synthesis and characterization of the molecular precursors and/or a systematic study of the use of different precursors or reaction conditions) or demonstrate a cutting-edge application (for example inorganic materials for energy applications). Papers dealing only with stability constants are not considered.