Enantioselective Addition of 3-hydroxyquinolin-2(1H)-one to Isatin and Pyrazole-4,5-dione Derived Ketimines

IF 4.6 1区化学 Q1 CHEMISTRY, ORGANIC Organic Chemistry Frontiers Pub Date : 2024-11-05 DOI:10.1039/d4qo01895h

Yue Wei, Guishun Bai, Jiamin Wu, Yi Hua, Tao Zhang, Congyong Yue, Hong Wang, Xiaoze Bao

引用次数: 0

Abstract

The enantioselective reactivity of 3-hydroxyquinolin-2(1H)-ones was developed through their addition to isatin and pyrazole-4,5-dione derived ketimines, affording novel architectures featuring multiple natural products scaffolds in high yield with excellent enantioselectivities. Gram-scale synthesis and synthetic transformations further disclosed the potential of current process.

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3- 羟基喹啉-2(1H)-酮与异靛红和吡唑-4,5-二酮衍生酮亚胺的对映选择性加成

通过将 3-羟基喹啉-2(1H)-酮与异靛红和吡唑-4,5-二酮衍生的酮亚胺进行加成，开发了其对映体选择性反应，从而以优异的对映体选择性高产率获得了具有多种天然产物支架的新型结构。革兰氏级合成和合成转化进一步揭示了当前工艺的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Organic Chemistry Frontiers CHEMISTRY, ORGANIC-

CiteScore

7.90

自引率

11.10%

发文量

686

审稿时长

1 months

期刊介绍： Organic Chemistry Frontiers is an esteemed journal that publishes high-quality research across the field of organic chemistry. It places a significant emphasis on studies that contribute substantially to the field by introducing new or significantly improved protocols and methodologies. The journal covers a wide array of topics which include, but are not limited to, organic synthesis, the development of synthetic methodologies, catalysis, natural products, functional organic materials, supramolecular and macromolecular chemistry, as well as physical and computational organic chemistry.