Role of non-coding RNA in lineage plasticity of prostate cancer.

IF 4.8 3区医学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Cancer gene therapy Pub Date : 2024-11-04 DOI:10.1038/s41417-024-00834-z

Wenhui Tan, Changkai Xiao, Min Ma, Youhan Cao, Zhenguo Huang, Xiaolan Wang, Ran Kang, Zhenfa Li, Ermao Li

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Abstract

The treatment of prostate cancer (PCa) has made great progress in recent years, but treatment resistance always develops and can even lead to fatal disease. Exploring the mechanism of drug resistance is of great significance for improving treatment outcomes and developing biomarkers with predictive value. It is increasingly recognized that mechanism of drug resistance in advanced PCa is related to lineage plasticity and tissue differentiation. Specifically, one of the mechanisms by which castration-resistant prostate cancer (CRPC) cells acquire drug resistance and transform into neuroendocrine prostate cancer (NEPC) cells is lineage plasticity. NEPC is a subtype of PCa that is highly aggressive and lethal, with a median survival of only 7 months. With the development of high-throughput RNA sequencing technology, more and more non-coding RNAs have been identified, which play important roles in different diseases through different mechanisms. Several ncRNAs have shown great potential in PCa lineage plasticity and as biomarkers. In the review, the role of ncRNA in PCa lineage plasticity and its use as biomarkers were reviewed.

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非编码 RNA 在前列腺癌血统可塑性中的作用

近年来，前列腺癌（PCa）的治疗取得了巨大进展，但治疗过程中总会出现耐药性，甚至会导致致命疾病。探索耐药机制对于改善治疗效果和开发具有预测价值的生物标志物具有重要意义。越来越多的人认识到，晚期 PCa 的耐药机制与细胞系可塑性和组织分化有关。具体来说，阉割耐药前列腺癌（CRPC）细胞获得耐药性并转化为神经内分泌前列腺癌（NEPC）细胞的机制之一是系可塑性。NEPC 是 PCa 的一种亚型，具有高度侵袭性和致命性，中位生存期仅为 7 个月。随着高通量 RNA 测序技术的发展，越来越多的非编码 RNA 被发现，它们通过不同机制在不同疾病中发挥重要作用。一些 ncRNA 在 PCa 系谱可塑性和生物标志物方面显示出巨大的潜力。这篇综述综述了 ncRNA 在 PCa 株系可塑性中的作用及其作为生物标志物的应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cancer gene therapy 医学-生物工程与应用微生物

CiteScore

10.20

自引率

0.00%

发文量

150

审稿时长

4-8 weeks

期刊介绍： Cancer Gene Therapy is the essential gene and cellular therapy resource for cancer researchers and clinicians, keeping readers up to date with the latest developments in gene and cellular therapies for cancer. The journal publishes original laboratory and clinical research papers, case reports and review articles. Publication topics include RNAi approaches, drug resistance, hematopoietic progenitor cell gene transfer, cancer stem cells, cellular therapies, homologous recombination, ribozyme technology, antisense technology, tumor immunotherapy and tumor suppressors, translational research, cancer therapy, gene delivery systems (viral and non-viral), anti-gene therapy (antisense, siRNA & ribozymes), apoptosis; mechanisms and therapies, vaccine development, immunology and immunotherapy, DNA synthesis and repair. Cancer Gene Therapy publishes the results of laboratory investigations, preclinical studies, and clinical trials in the field of gene transfer/gene therapy and cellular therapies as applied to cancer research. Types of articles published include original research articles; case reports; brief communications; review articles in the main fields of drug resistance/sensitivity, gene therapy, cellular therapy, tumor suppressor and anti-oncogene therapy, cytokine/tumor immunotherapy, etc.; industry perspectives; and letters to the editor.