Positive association of the thigh muscle thickness to intracellular-water ratio with handgrip strength, but not with the risk of mortality in hospitalized cancer patients: a longitudinal study.

IF 3.6 3区 医学 Q2 NUTRITION & DIETETICS European Journal of Clinical Nutrition Pub Date : 2024-11-04 DOI:10.1038/s41430-024-01532-7
Tatyanne L N Gomes, Jessica F M Ivo, Lara G Mainardi, Gustavo D Pimentel
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Abstract

This study explored the relationship between handgrip strength, muscle thickness, and the intracellular water ratio (MT/ICW) in cancer patients. It aimed to identify a cut-off point for the MT/ICW ratio that might influence survival. Conducted as an exploratory, longitudinal study in a public hospital, it included patients from 2018 to 2022, with follow-up until August 31, 2023. The cut-off for the MT/ICW ratio was determined based on its sensitivity for mortality. Results indicated that patients with an MT/ICW ratio >0.97 had significantly lower extracellular water percentages and greater muscle thickness. A positive association was found between the MT/ICW ratio and handgrip strength, even after adjusting for age, sex, extracellular water, and body mass index. However, patients with an MT/ICW ratio ≤0.97 showed no significant mortality risk. In conclusion, MT/ICW ratio >0.97 mm/L in hospitalized cancer patients was positively associated with handgrip strength, but not risk of mortality.

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一项纵向研究发现,大腿肌肉厚度与细胞内水分比值与手握力呈正相关,但与住院癌症患者的死亡风险无关。
本研究探讨了癌症患者的手握力、肌肉厚度和细胞内水比率(MT/ICW)之间的关系。研究旨在确定可能影响生存的 MT/ICW 比值临界点。该研究是在一家公立医院进行的一项探索性纵向研究,研究对象包括2018年至2022年的患者,随访至2023年8月31日。MT/ICW 比值的临界值是根据其对死亡率的敏感性确定的。结果表明,MT/ICW 比值大于 0.97 的患者细胞外水百分比显著较低,肌肉厚度较大。即使对年龄、性别、细胞外水分和体重指数进行调整后,也发现 MT/ICW 比值与握力之间存在正相关。然而,MT/ICW 比值≤0.97 的患者没有明显的死亡风险。总之,住院癌症患者的 MT/ICW 比值大于 0.97 mm/L 与手握力呈正相关,但与死亡风险无关。
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来源期刊
CiteScore
10.60
自引率
2.10%
发文量
189
审稿时长
3-6 weeks
期刊介绍: The European Journal of Clinical Nutrition (EJCN) is an international, peer-reviewed journal covering all aspects of human and clinical nutrition. The journal welcomes original research, reviews, case reports and brief communications based on clinical, metabolic and epidemiological studies that describe methodologies, mechanisms, associations and benefits of nutritional interventions for clinical disease and health promotion. Topics of interest include but are not limited to: Nutrition and Health (including climate and ecological aspects) Metabolism & Metabolomics Genomics and personalized strategies in nutrition Nutrition during the early life cycle Health issues and nutrition in the elderly Phenotyping in clinical nutrition Nutrition in acute and chronic diseases The double burden of ''malnutrition'': Under-nutrition and Obesity Prevention of Non Communicable Diseases (NCD)
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