Navigating the immune landscape with plasma cells: A pan-cancer signature for precision immunotherapy.

IF 5 3区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY BioFactors Pub Date : 2024-11-04 DOI:10.1002/biof.2142
Bicheng Ye, Aimin Jiang, Feng Liang, Changcheng Wang, Xiaoqing Liang, Pengpeng Zhang
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Abstract

Immunotherapy has revolutionized cancer treatment; however, predicting patient response remains a significant challenge. Our study identified a novel plasma cell signature, Plasma cell.Sig, through a pan-cancer single-cell RNA sequencing analysis, which predicts patient outcomes to immunotherapy with remarkable accuracy. The signature was developed using rigorous machine learning algorithms and validated across multiple cohorts, demonstrating superior predictive power with an area under the curve (AUC) exceeding 0.7. Notably, the low-risk group, as classified by Plasma cell.Sig, exhibited enriched immune cell infiltration and heightened tumor immunogenicity, indicating an enhanced responsiveness to immunotherapy. Conversely, the high-risk group showed reduced immune activity and potential mechanisms of immune evasion. These findings not only enhance understanding of the intrinsic and extrinsic immune landscapes within the tumor microenvironment but also pave the way for more precise, biomarker-guided immunotherapy approaches in oncology.

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用浆细胞驾驭免疫环境:精准免疫疗法的泛癌症特征。
免疫疗法给癌症治疗带来了革命性的变化;然而,预测患者的反应仍然是一项重大挑战。我们的研究通过泛癌症单细胞 RNA 测序分析发现了一种新型浆细胞特征 Plasma cell.Sig,它能准确预测患者对免疫疗法的疗效。该特征采用严格的机器学习算法开发,并在多个队列中得到验证,显示出卓越的预测能力,曲线下面积(AUC)超过0.7。值得注意的是,根据 Plasma cell.Sig 分类的低风险组显示出丰富的免疫细胞浸润和肿瘤免疫原性增强,表明对免疫疗法的反应性增强。相反,高危组则表现出免疫活性降低和潜在的免疫逃避机制。这些发现不仅加深了人们对肿瘤微环境中内在和外在免疫环境的了解,还为肿瘤学中更精确的、以生物标记物为指导的免疫疗法铺平了道路。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
BioFactors
BioFactors 生物-内分泌学与代谢
CiteScore
11.50
自引率
3.30%
发文量
96
审稿时长
6-12 weeks
期刊介绍: BioFactors, a journal of the International Union of Biochemistry and Molecular Biology, is devoted to the rapid publication of highly significant original research articles and reviews in experimental biology in health and disease. The word “biofactors” refers to the many compounds that regulate biological functions. Biological factors comprise many molecules produced or modified by living organisms, and present in many essential systems like the blood, the nervous or immunological systems. A non-exhaustive list of biological factors includes neurotransmitters, cytokines, chemokines, hormones, coagulation factors, transcription factors, signaling molecules, receptor ligands and many more. In the group of biofactors we can accommodate several classical molecules not synthetized in the body such as vitamins, micronutrients or essential trace elements. In keeping with this unified view of biochemistry, BioFactors publishes research dealing with the identification of new substances and the elucidation of their functions at the biophysical, biochemical, cellular and human level as well as studies revealing novel functions of already known biofactors. The journal encourages the submission of studies that use biochemistry, biophysics, cell and molecular biology and/or cell signaling approaches.
期刊最新文献
Construction of lysosome-related prognostic signature to predict the survival outcomes and selecting suitable drugs for patients with HNSCC. Navigating the immune landscape with plasma cells: A pan-cancer signature for precision immunotherapy. Machine learning models reveal ARHGAP11A's impact on lymph node metastasis and stemness in NSCLC. The carcinogenesis of esophageal squamous cell cancer is positively regulated by USP13 through WISP1 deubiquitination. Piperine: an emerging biofactor with anticancer efficacy and therapeutic potential.
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