Muhammad Babar Khawar, Ali Afzal, Shuangshuang Dong, Yue Si, Haibo Sun
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引用次数: 0
Abstract
Abstract: Colorectal cancer (CRC), a major global health concern, necessitates innovative treatments. Chimeric antigen receptor (CAR) T cells have shown promise, yet they grapple with challenges. The spotlight pivots to the rising heroes: CAR natural killer (NK) cells, offering advantages such as higher safety profiles, cost-effectiveness, and efficacy against solid tumors. Nevertheless, the specific mechanisms underlying CAR NK cell trafficking and their interplay within the complex tumor microenvironment require further in-depth exploration. Herein, we provide insights into the design and engineering of CAR NK cells, antigen targets in CRC, and success in overcoming resistance mechanisms with an emphasis on the potential for clinical trials.
摘要：结直肠癌（CRC）是全球关注的主要健康问题，需要创新的治疗方法。嵌合抗原受体（CAR）T 细胞已显示出治疗前景，但它们也面临着挑战。聚光灯转向正在崛起的英雄：CAR 自然杀伤（NK）细胞具有更高的安全性、成本效益和对实体瘤的疗效等优势。然而，CAR NK 细胞在复杂的肿瘤微环境中的迁移及其相互作用的具体机制还需要进一步深入探讨。在此，我们将深入探讨 CAR NK 细胞的设计和工程、CRC 中的抗原靶点以及克服耐药机制的成功经验，并重点介绍临床试验的潜力。
期刊介绍：
The Chinese Medical Journal (CMJ) is published semimonthly in English by the Chinese Medical Association, and is a peer reviewed general medical journal for all doctors, researchers, and health workers regardless of their medical specialty or type of employment. Established in 1887, it is the oldest medical periodical in China and is distributed worldwide. The journal functions as a window into China’s medical sciences and reflects the advances and progress in China’s medical sciences and technology. It serves the objective of international academic exchange. The journal includes Original Articles, Editorial, Review Articles, Medical Progress, Brief Reports, Case Reports, Viewpoint, Clinical Exchange, Letter,and News,etc. CMJ is abstracted or indexed in many databases including Biological Abstracts, Chemical Abstracts, Index Medicus/Medline, Science Citation Index (SCI), Current Contents, Cancerlit, Health Plan & Administration, Embase, Social Scisearch, Aidsline, Toxline, Biocommercial Abstracts, Arts and Humanities Search, Nuclear Science Abstracts, Water Resources Abstracts, Cab Abstracts, Occupation Safety & Health, etc. In 2007, the impact factor of the journal by SCI is 0.636, and the total citation is 2315.
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