Statin use and ovarian cancer outcomes.

IF 2.9 3区医学 Q2 ONCOLOGY Expert Review of Anticancer Therapy Pub Date : 2024-11-10 DOI:10.1080/14737140.2024.2426551

John P Micha, Mark A Rettenmaier, Randy D Bohart, Bram H Goldstein

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Abstract

Introduction: Ovarian cancer contributed to 13,270 patient deaths in the United States during 2023 and is considered the most aggressive gynecologic malignancy. While surgery, chemotherapy and targeted medications have improved ovarian cancer patient outcomes, novel therapies that further bolster treatment efficacy without compromising toxicity represent an unmet clinical need.

Areas covered: In the current review, we assessed the reported studies involving statin use and ovarian cancer outcomes; a preponderance of the evidence indicated that statins confer a survival benefit in ovarian cancer, especially for patients who underwent treatment post-diagnosis and for a prolonged interval.

Expert opinion: The evidence involving a potential survival benefit from statin use in ovarian cancer remains controversial, especially with hydrophilic statins (e.g. pravastatin). While statin users may exhibit better ovarian cancer survival outcomes than non-statin users, additional research should evaluate the putative clinical benefits of statins in ovarian cancer via randomized controlled trials.

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他汀类药物的使用与卵巢癌的结果。

导言：2023 年，卵巢癌导致美国 13,270 名患者死亡，被认为是最具侵袭性的妇科恶性肿瘤。虽然手术、化疗和靶向药物改善了卵巢癌患者的预后，但能在不影响毒性的前提下进一步提高治疗效果的新型药物仍是一项尚未满足的临床需求：在本综述中，我们评估了已报道的涉及他汀类药物的使用和卵巢癌预后的研究；大部分证据表明，他汀类药物可使卵巢癌患者生存获益，尤其是对诊断后接受他汀类药物治疗且间隔时间较长的患者：他汀类药物对卵巢癌患者的生存有潜在益处的证据仍存在争议，尤其是亲水性他汀类药物（如普伐他汀）。虽然他汀类药物使用者的卵巢癌存活率可能高于非他汀类药物使用者，但更多的研究应通过随机对照试验来评估他汀类药物对卵巢癌患者存活率的潜在益处。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Expert Review of Anticancer Therapy 医学-肿瘤学

CiteScore

5.10

自引率

3.00%

发文量

100

审稿时长

4-8 weeks

期刊介绍： Expert Review of Anticancer Therapy (ISSN 1473-7140) provides expert appraisal and commentary on the major trends in cancer care and highlights the performance of new therapeutic and diagnostic approaches. Coverage includes tumor management, novel medicines, anticancer agents and chemotherapy, biological therapy, cancer vaccines, therapeutic indications, biomarkers and diagnostics, and treatment guidelines. All articles are subject to rigorous peer-review, and the journal makes an essential contribution to decision-making in cancer care. Comprehensive coverage in each review is complemented by the unique Expert Review format and includes the following sections: Expert Opinion - a personal view of the data presented in the article, a discussion on the developments that are likely to be important in the future, and the avenues of research likely to become exciting as further studies yield more detailed results Article Highlights – an executive summary of the author’s most critical points.