Prediction values of fat-soluble vitamin of growth retardation in children aged 1-6 years.

IF 2.1 3区医学 Q2 PEDIATRICS Frontiers in Pediatrics Pub Date : 2024-10-21 eCollection Date: 2024-01-01 DOI:10.3389/fped.2024.1315115

Qingqing Yan, Qingwen Zhu, Chen Jiang, Lingli Zhang, Xiaojing Xu

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Abstract

Background: Retardation among children is a persistent global health concern. Vitamin deficiency in childhood may contribute to growth retardation; however, its causal effects are not fully understood.

Objective: Here, we aimed to explore the prediction values of fat-soluble vitamin levels on GR in children aged 1-6 years.

Methods: 614 children aged from 1 to 6 years at Nantong Maternal and Child Care Health Hospital between January 2021 and December 2022 in this retrospective observational study participated in the assessment of developmental status and blood detection of vitamin from peripheral blood (PB). The relationship between vitamin levels and GR was analyzed by Multivariable logistic regression analysis.

Results: Developmental assessment results showed that 132 cases from 614 with growth retardation (21.50%). Statistical analysis showed children with GR were more likely to be males (59.45% vs. 40.55%, p = 0.191). The age of children with GR was significantly higher than those without GR (p < 0.01). Importantly, the levels of various fat-soluble vitamins in GR individuals were significantly lower than those in normal individuals. ROC analysis showed that vitamin E, vitamin A and 25(OH) D₃ were less effective in predicting GR model (AUC: 0.87, 0.74, and 0.65,). However, the combination of vitamin E, vitamin A and 25(OH)D₃ with age was effective in predicting GR. (AUC: 0.84, 0.77, 0.75).

Conclusion: The combination of 25(OH)D3, Vitamin E, Vitamin A with age may have good predictive performance for children GR aged 1-6 years.

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1-6 岁儿童生长迟缓的脂溶性维生素预测值。

背景：儿童发育迟缓是全球持续关注的健康问题。方法：2021年1月至2022年12月，南通市妇幼保健院对614名1-6岁儿童进行了发育状况评估和外周血（PB）维生素检测。通过多变量逻辑回归分析了维生素水平与GR之间的关系：发育评估结果显示，614 例儿童中有 132 例发育迟缓（21.50%）。统计分析显示，患有生长迟缓症的儿童男性比例更高（59.45% vs. 40.55%，P = 0.191）。患有 GR 的儿童的年龄明显高于未患有 GR 的儿童（P=0.191）。然而，维生素 E、维生素 A 和 25（OH）D3 与年龄的结合对预测 GR 很有效（AUC：0.84、0.74 和 0.65）。(AUC：0.84、0.77、0.75）：结论：25（OH）D3、维生素 E、维生素 A 与年龄的结合可能对 1-6 岁儿童 GR 具有良好的预测效果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Frontiers in Pediatrics Medicine-Pediatrics, Perinatology and Child Health

CiteScore

3.60

自引率

7.70%

发文量

2132

审稿时长

14 weeks

期刊介绍： Frontiers in Pediatrics (Impact Factor 2.33) publishes rigorously peer-reviewed research broadly across the field, from basic to clinical research that meets ongoing challenges in pediatric patient care and child health. Field Chief Editors Arjan Te Pas at Leiden University and Michael L. Moritz at the Children''s Hospital of Pittsburgh are supported by an outstanding Editorial Board of international experts. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide. Frontiers in Pediatrics also features Research Topics, Frontiers special theme-focused issues managed by Guest Associate Editors, addressing important areas in pediatrics. In this fashion, Frontiers serves as an outlet to publish the broadest aspects of pediatrics in both basic and clinical research, including high-quality reviews, case reports, editorials and commentaries related to all aspects of pediatrics.