The association of the triglyceride-glucose index with Alzheimer's disease and its potential mechanisms.

IF 3.4 3区医学 Q2 NEUROSCIENCES Journal of Alzheimer's Disease Pub Date : 2024-11-01 Epub Date: 2024-10-17 DOI:10.1177/13872877241284216

Zihao Zhang, Zehu Sheng, Jiayao Liu, Dandan Zhang, Hao Wang, Lanyang Wang, Yangke Zhu, Lingzhi Ma, Lan Tan

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Abstract

Background: The correlation between Alzheimer's disease (AD) and the glucose-triglyceride (TyG) index remains undetermined.

Objective: This study aimed to investigate the relationship between the TyG index and AD, as well as the relationship between the TyG index and cerebrospinal fluid (CSF) AD biomarkers and cognition.

Methods: Six hundred twenty-eight non-dementia participants were included. The TyG index, pathological markers, and cognitive measures were studied using multiple linear regression. Also calculated using a multivariate Cox regression model were the hazard ratio (HR) and its 95% confidence interval (CI). Ten thousand bootstrap iterative causal mediation analyses were performed to investigate the potential mediating effect of AD pathology on cognition.

Results: The TyG index was linked to CSF AD biomarkers (β_Aβ42= 0.880; β_Tau= -0.674; β_pTau= -0.884; β_Aβ42/pTau= 1.764; β_Aβ42/Tau= 1.554; β_pTau/Tau= -0.210) and cognitive measurements (β_MEM= 0.570; β_EF= 0.535; β_ADAS11= -0.789). Mediation analysis revealed that the TyG index may influence cognition via CSF AD biomarkers, including Aβ₄₂, tau, and pTau. Furthermore, each 1-unit increase in TyG index was associated with a 29.5% reduction in the risk of incident AD.

Conclusions: A delayed rate of cognitive decline and a reduced risk of AD were found to be correlated with higher levels of the TyG index, but this does not mean increasing TyG index levels is beneficial for health. Through AD pathology, the TyG index may influence AD and cognitive changes.

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甘油三酯-葡萄糖指数与阿尔茨海默病的关联及其潜在机制。

背景：阿尔茨海默病（AD）与葡萄糖甘油三酯（TyG）指数之间的相关性仍未确定：阿尔茨海默病（AD）与葡萄糖-甘油三酯（TyG）指数之间的相关性仍未确定：本研究旨在调查TyG指数与AD之间的关系，以及TyG指数与脑脊液（CSF）AD生物标志物和认知之间的关系：方法：纳入628名非痴呆症参与者。采用多元线性回归法研究了TyG指数、病理标记物和认知指标。使用多元 Cox 回归模型还计算了危险比（HR）及其 95% 置信区间（CI）。为了研究AD病理学对认知的潜在中介效应，进行了一万次引导迭代因果中介分析：结果：TyG指数与CSF AD生物标志物（βAβ42 = 0.880；βTau = -0.674；βpTau = -0.884；βAβ42/pTau = 1.764；βAβ42/Tau = 1.554；βpTau/Tau = -0.210）和认知测量（βMEM = 0.570；βEF = 0.535；βADAS11 = -0.789）相关。中介分析显示，TyG指数可能会通过脑脊液AD生物标志物（包括Aβ42、tau和pTau）影响认知。此外，TyG指数每增加1个单位，AD发病风险就会降低29.5%：结论：研究发现，认知能力衰退速度的延迟和AD风险的降低与较高的TyG指数水平相关，但这并不意味着提高TyG指数水平对健康有益。通过AD病理学，TyG指数可能会影响AD和认知的变化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Alzheimer's Disease 医学-神经科学

CiteScore

6.40

自引率

7.50%

发文量

1327

审稿时长

2 months

期刊介绍： The Journal of Alzheimer''s Disease (JAD) is an international multidisciplinary journal to facilitate progress in understanding the etiology, pathogenesis, epidemiology, genetics, behavior, treatment and psychology of Alzheimer''s disease. The journal publishes research reports, reviews, short communications, hypotheses, ethics reviews, book reviews, and letters-to-the-editor. The journal is dedicated to providing an open forum for original research that will expedite our fundamental understanding of Alzheimer''s disease.