A Comprehensive Review of Antimicrobial Agents Against Clinically Important Bacterial Pathogens: Prospects for Phytochemicals.

IF 6.1 2区 医学 Q1 CHEMISTRY, MEDICINAL Phytotherapy Research Pub Date : 2024-11-04 DOI:10.1002/ptr.8365
Soumyadip Ghosh, Soumya Basu, Anand Anbarasu, Sudha Ramaiah
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Abstract

Antimicrobial resistance (AMR) hinders the effective treatment of a range of bacterial infections, posing a serious threat to public health globally, as it challenges the currently available antimicrobial drugs. Among the various modes of antimicrobial action, antimicrobial agents that act on membranes have the most promising efficacy. However, there are no consolidated reports on the shortcomings of these drugs, existing challenges, or the potential applications of phytochemicals that act on membranes. Therefore, in this review, we have addressed the challenges and focused on various phytochemicals as antimicrobial agents acting on the membranes of clinically important bacterial pathogens. Antibacterial phytochemicals comprise diverse group of agents found in a wide range of plants. These compounds have been found to disrupt cell membranes, inhibit enzymes, interfere with protein synthesis, generate reactive oxygen species, modulate quorum sensing, and inhibit bacterial adhesion, making them promising candidates for the development of novel antibacterial therapies. Recently, polyphenolic compounds have been reported to have proven efficacy against nosocomial multidrug-resistant pathogens. However, more high-quality studies, improved standards, and the adoption of rules and regulations are required to firmly confirm the clinical efficacy of phytochemicals derived from plants. Identifying potential challenges, thrust areas of research, and considering viable approaches is essential for the successful clinical translation of these compounds.

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针对临床重要细菌病原体的抗菌剂综述:植物化学物质的前景。
抗菌药耐药性(AMR)阻碍了一系列细菌感染的有效治疗,对全球公共卫生构成严重威胁,因为它对目前可用的抗菌药提出了挑战。在各种抗菌作用模式中,作用于薄膜的抗菌剂具有最有希望的疗效。然而,目前还没有关于这些药物的缺点、现有挑战或作用于膜的植物化学物质的潜在应用的综合报告。因此,在本综述中,我们针对这些挑战,重点介绍了作为抗菌剂作用于临床上重要细菌病原体膜的各种植物化学物质。抗菌植物化学物质包括在多种植物中发现的各种物质。已发现这些化合物能破坏细胞膜、抑制酶、干扰蛋白质合成、产生活性氧、调节法定人数感应和抑制细菌粘附,因此很有希望成为开发新型抗菌疗法的候选物质。最近有报道称,多酚类化合物已被证实对鼻腔多药耐药性病原体具有疗效。然而,还需要更多高质量的研究、更完善的标准以及更严格的规章制度,才能牢固确立从植物中提取的植物化学物质的临床疗效。确定潜在的挑战、研究的重点领域并考虑可行的方法,对于这些化合物的成功临床转化至关重要。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Phytotherapy Research
Phytotherapy Research 医学-药学
CiteScore
12.80
自引率
5.60%
发文量
325
审稿时长
2.6 months
期刊介绍: Phytotherapy Research is an internationally recognized pharmacological journal that serves as a trailblazing resource for biochemists, pharmacologists, and toxicologists. We strive to disseminate groundbreaking research on medicinal plants, pushing the boundaries of knowledge and understanding in this field. Our primary focus areas encompass pharmacology, toxicology, and the clinical applications of herbs and natural products in medicine. We actively encourage submissions on the effects of commonly consumed food ingredients and standardized plant extracts. We welcome a range of contributions including original research papers, review articles, and letters. By providing a platform for the latest developments and discoveries in phytotherapy, we aim to support the advancement of scientific knowledge and contribute to the improvement of modern medicine.
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