Are background breast parenchymal features on preoperative breast MRI associated with disease-free survival in patients with invasive breast cancer?

IF 9.7 1区医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Radiologia Medica Pub Date : 2024-11-04 DOI:10.1007/s11547-024-01914-8

Jin You Kim, Jin Joo Kim, Ji Won Lee, Nam Kyung Lee, Suk Kim, Kyung Jin Nam, Kyeyoung Lee, Ki Seok Choo

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Abstract

Objective: To evaluate whether breast parenchymal features of the contralateral breast on preoperative MRI are associated with primary breast cancer characteristics and disease-free survival (DFS) in women with invasive breast cancer.

Materials and methods: Women with newly diagnosed invasive breast cancer who underwent preoperative breast MRI followed by surgery were retrospectively evaluated. Background parenchymal enhancement (BPE) on dynamic contrast-enhanced MRI and background diffusion signal (BDS) on diffusion-weighted MRI of the contralateral breast were qualitatively assessed using a four-category scale: minimal, mild, moderate, or marked. Primary breast cancer characteristics were compared based on the degree of BPE or BDS. Cox proportional hazards models were used to evaluate the association between MRI parenchymal features and DFS after adjusting for clinicopathologic features.

Results: A total of 515 women (mean age, 54 years) were included. Of whom, 46 (8.9%) patients who developed disease recurrence at a median follow-up of 60 months were observed. A high level (moderate/marked) of BPE or BDS was associated with younger age (≤ 45) and premenopausal status (all P < 0.05) compared to a low level (minimal/mild), but it was not associated with primary cancer characteristics such as tumor stage, grade, or subtype. Multivariable Cox proportional hazards analysis demonstrated that larger tumor size (> 2 cm) (hazard ratio [HR], 3.877; P < . 001), triple-negative subtype (HR, 2.440; P = .013), and axillary node metastasis (HR, 1.823; P = .049) were associated with worse DFS. No associations were observed between background parenchymal features and disease outcomes.

Conclusions: MRI parenchymal features, including BPE and BDS, of the contralateral breast showed no associations with primary breast cancer characteristics or DFS in women with invasive breast cancer.

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浸润性乳腺癌患者术前乳腺磁共振成像显示的乳腺实质特征与无病生存率是否相关？

摘要评估术前磁共振成像显示的对侧乳房实质特征是否与浸润性乳腺癌女性患者的原发性乳腺癌特征和无病生存期（DFS）相关：对新确诊的浸润性乳腺癌患者进行回顾性评估，这些患者术前接受了乳腺磁共振成像检查，随后进行了手术。对动态对比增强 MRI 的背景实质增强（BPE）和对侧乳腺弥散加权 MRI 的背景弥散信号（BDS）进行定性评估，评估分为四级：极小、轻度、中度或明显。根据 BPE 或 BDS 的程度比较原发性乳腺癌的特征。在调整临床病理特征后，采用Cox比例危险模型评估MRI实质特征与DFS之间的关系：共纳入 515 名女性（平均年龄 54 岁）。在中位随访 60 个月时，观察到其中 46 例（8.9%）患者出现疾病复发。高水平（中度/明显）的 BPE 或 BDS 与年轻（≤ 45 岁）和绝经前状态（均为 P 2 cm）有关（危险比 [HR]，3.877；P 结论：BPE 或 BDS 的高水平与年龄和绝经前状态有关：患浸润性乳腺癌的妇女对侧乳房的 MRI 实质特征（包括 BPE 和 BDS）与原发性乳腺癌特征或 DFS 无关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Radiologia Medica 医学-核医学

CiteScore

14.10

自引率

7.90%

发文量

133

审稿时长

4-8 weeks

期刊介绍： Felice Perussia founded La radiologia medica in 1914. It is a peer-reviewed journal and serves as the official journal of the Italian Society of Medical and Interventional Radiology (SIRM). The primary purpose of the journal is to disseminate information related to Radiology, especially advancements in diagnostic imaging and related disciplines. La radiologia medica welcomes original research on both fundamental and clinical aspects of modern radiology, with a particular focus on diagnostic and interventional imaging techniques. It also covers topics such as radiotherapy, nuclear medicine, radiobiology, health physics, and artificial intelligence in the context of clinical implications. The journal includes various types of contributions such as original articles, review articles, editorials, short reports, and letters to the editor. With an esteemed Editorial Board and a selection of insightful reports, the journal is an indispensable resource for radiologists and professionals in related fields. Ultimately, La radiologia medica aims to serve as a platform for international collaboration and knowledge sharing within the radiological community.