Fucoidan Ameliorates Testosterone-Induced Benign Prostatic Hyperplasia (BPH) in Rats.

IF 2 Q2 UROLOGY & NEPHROLOGY Research and Reports in Urology Pub Date : 2024-10-30 eCollection Date: 2024-01-01 DOI:10.2147/RRU.S478740

Devanand Shanmugasundaram, Corinna Dwan, Barbara C Wimmer, Shalini Srivastava

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Abstract

Purpose: Benign prostatic hyperplasia (BPH) is a major urological health issue for men globally. Fucoidan, a sulfated polysaccharide, displays diverse bioactivities such as anti-inflammatory, anti-tumor, antioxidant, and immunoregulatory effects. This 28-day study examined the effects of Undaria pinnatifida fucoidan on testosterone-induced BPH in rats.

Methods: Forty-eight Sprague Dawley (SD) rats were randomly divided into six groups; G1- vehicle control, G2- testosterone alone BPH control group (3 mg/kg), G3- finasteride (10 mg/kg) + testosterone, G4- fucoidan (40 mg/kg) + testosterone, G5- fucoidan (400 mg/kg) + testosterone, and G6- fucoidan alone (400 mg/kg). The animals were observed for clinical signs, body weight, feed consumption, prostate weight, prostate index, and biochemical markers such as tumor necrosis factor-alpha (TNF-α), interleukin- 1β (IL-1β), prostate-specific antigen (PSA) and messenger ribonucleic acid (mRNA) expression of BCL-2-associated X protein (BAX) and B-cell lymphoma-2 (BCL-2) in serum. Testosterone and dihydrotestosterone (DHT) levels were evaluated in both serum and prostate.

Results: Fucoidan significantly prevented an increase in prostate weight and prostate index induced by testosterone. DHT levels in the prostate of the intervention groups were significantly lower than in the BPH control group (p <0.05); however, no significant difference was observed in serum levels. Similarly, a significant reduction was observed in serum and prostate testosterone levels in the intervention groups compared to the BPH control group (p <0.05). Biochemical analyses showed PSA levels were significantly lower in the fucoidan groups compared to the BPH control group (p<0.05). Although not statistically significant, fucoidan groups showed a trend of reducing IL-1β and TNF-α levels. Fucoidan demonstrated pro-apoptotic potential in its ability to decrease BCL-2 and increase BAX. Histopathological evidence revealed fewer microscopic lesions in the fucoidan groups compared to the BPH control group.

Conclusion: The results suggest Undaria pinnatifida fucoidan can reduce testosterone-induced BPH symptoms in SD rats.

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褐藻糖胶可改善睾酮诱发的大鼠良性前列腺增生症（BPH）。

目的：良性前列腺增生症（BPH）是全球男性主要的泌尿系统健康问题。褐藻糖胶是一种硫酸化多糖，具有多种生物活性，如抗炎、抗肿瘤、抗氧化和免疫调节作用。这项为期28天的研究考察了裙带菜褐藻糖胶对睾酮诱导的大鼠良性前列腺增生症的影响：48只Sprague Dawley（SD）大鼠被随机分为6组：G1-药物对照组，G2-单用睾酮良性前列腺增生对照组（3 mg/kg），G3-非那雄胺（10 mg/kg）+睾酮组，G4-褐藻糖胶（40 mg/kg）+睾酮组，G5-褐藻糖胶（400 mg/kg）+睾酮组，G6-单用褐藻糖胶（400 mg/kg）组。观察动物的临床症状、体重、饲料消耗量、前列腺重量、前列腺指数，以及血清中肿瘤坏死因子-α（TNF-α）、白细胞介素-1β（IL-1β）、前列腺特异性抗原（PSA）、BCL-2相关X蛋白（BAX）和B细胞淋巴瘤-2（BCL-2）的信使核糖核酸（mRNA）表达等生化指标。对血清和前列腺中的睾酮和双氢睾酮（DHT）水平进行了评估：结果：褐藻糖胶能明显防止睾酮引起的前列腺重量和前列腺指数的增加。干预组前列腺中的 DHT 水平明显低于良性前列腺增生症对照组（p 结论：褐藻糖胶能有效抑制睾酮引起的前列腺重量和前列腺指数的增加：结果表明，裙带菜褐藻糖胶可减轻睾酮诱导的SD大鼠良性前列腺增生症状。

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来源期刊

Research and Reports in Urology UROLOGY & NEPHROLOGY-

CiteScore

3.40

自引率

0.00%

发文量

审稿时长

16 weeks

期刊介绍： Research and Reports in Urology is an international, peer-reviewed, open access, online journal. Publishing original research, reports, editorials, reviews and commentaries on all aspects of adult and pediatric urology in the clinic and laboratory including the following topics: Pathology, pathophysiology of urological disease Investigation and treatment of urological disease Pharmacology of drugs used for the treatment of urological disease Although the main focus of the journal is to publish research and clinical results in humans; preclinical, animal and in vitro studies will be published where they will shed light on disease processes and potential new therapies. Issues of patient safety and quality of care will also be considered.