Resilience and spiritual well-being as resources for coping with radiotherapy and surviving in patients with glioblastoma.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2024-11-05 DOI:10.1017/S1478951524001111

Loredana Dinapoli, Morena Caliandro, Silvia Chiesa, Elisa Marconi, Nikola Dino Capocchiano, Ciro Mazzarella, Francesco Beghella Bartoli, Serena Bracci, Mario Balducci, Daniela Pia Rosaria Chieffo, Alba Fiorentino, Vincenzo Valentini, Luca Tagliaferri, Maria Antonietta Gambacorta, Nicola Dinapoli

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Abstract

Objectives: The primary aims of this multicenter, prospective observational study were to investigate spiritual well-being, resilience, and psychosocial distress in an Italian sample of glioblastoma patients undergoing radiochemotherapy. The secondary aim was to explore the influence of demographic, clinical, and psychological characteristics on survival.

Methods: The assessment was conducted only once, within the first week of radiochemotherapy treatment. Spiritual well-being was evaluated by the Functional Assessment of Chronic Illness Therapy-Spiritual Well-being (FACIT-Sp-12), and religious/spiritual beliefs and practices were evaluated by the System of Belief Inventory. Resilience was evaluated by the Connor-Davidson Resilience Scale (CD-RISC). Psychosocial distress was evaluated the by Distress Thermometer and Hospital Anxiety Depression Scale. We conducted an univariable analysis of overall survival (OS) using data from the most recent follow-up available, considering demographic and clinical variables that could influence survival. Follow-up was defined as either the time of death or the latest follow-up visit recorded.

Results: We recruited 104 patients, and the median follow-up time was 18.3 months. "Distressed" patients had lower scores than "not distressed" patients on the FACIT-Sp-12 and CD-RISC. While OS was not significant according to the FACIT-Sp-12 threshold, the Kaplan-Meier log-rank test was 0.05 according to the CD-RISC threshold. Among demographic variables, age showed significant associations with OS (p = 0.011). Resilience showed significant associations with OS (p = 0.025).

Significance of results: Data showed that high spiritual well-being was associated with high resilience and an absence of psychosocial distress in our sample of glioblastoma patients undergoing radiochemotherapy. Patients with greater resilience survived longer than those with lesser resilience. Profiling spiritual well-being and resilience in glioblastoma patients undergoing radiochemotherapy can be seen as a resource to identify novel characteristics to improve clinical take-in-charge of glioblastoma patients.

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复原力和精神健康是胶质母细胞瘤患者应对放疗和生存的资源。

研究目的这项多中心前瞻性观察研究的主要目的是调查接受放化疗的意大利样本胶质母细胞瘤患者的精神健康、复原力和心理社会问题。次要目的是探讨人口、临床和心理特征对生存的影响：评估只进行一次，即在接受放化疗的第一周内。精神健康通过慢性疾病治疗功能评估-精神健康（FACIT-Sp-12）进行评估，宗教/精神信仰和实践通过信仰系统量表进行评估。复原力通过康纳-戴维森复原力量表（CD-RISC）进行评估。社会心理压力通过压力温度计和医院焦虑抑郁量表进行评估。考虑到可能影响生存率的人口统计学和临床变量，我们使用最新随访数据对总生存率（OS）进行了单变量分析。随访时间定义为死亡时间或记录的最近一次随访时间：我们共招募了 104 名患者，中位随访时间为 18.3 个月。在FACIT-Sp-12和CD-RISC中，"窘迫 "患者的得分低于 "非窘迫 "患者。虽然根据 FACIT-Sp-12 临界值，OS 并不显著，但根据 CD-RISC 临界值，Kaplan-Meier 对数秩检验结果为 0.05。在人口统计学变量中，年龄与 OS 有显著相关性（p = 0.011）。复原力与 OS 有明显关系（p = 0.025）：数据显示，在接受放化疗的胶质母细胞瘤患者样本中，高精神幸福感与高复原力和无心理社会困扰相关。复原力较高的患者比复原力较低的患者存活时间更长。对接受放化疗的胶质母细胞瘤患者的精神健康和复原力进行分析，可作为一种资源，用于确定新的特征，以改善胶质母细胞瘤患者的临床治疗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.

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