On the targeting of voltage-gated calcium channels to neurotransmitter release sites

IF 4.8 2区 医学 Q1 NEUROSCIENCES Current Opinion in Neurobiology Pub Date : 2024-11-04 DOI:10.1016/j.conb.2024.102931
Morven Chin, Pascal S. Kaeser
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Abstract

At the presynaptic active zone, voltage-gated Ca2+ channels (CaVs) mediate Ca2+ entry for neurotransmitter release. CaVs are a large family of proteins, and different subtypes have distinct localizations across neuronal somata, dendrites and axons. Here, we review how neurons establish and maintain a specific CaV repertoire at their active zones. We focus on molecular determinants for cargo assembly, presynaptic delivery and release site tethering, and we discuss recent work that has identified key roles of the CaV intracellular C-terminus. Finally, we evaluate how these mechanisms may differ between different types of neurons. Work on CaVs provides insight into the protein targeting pathways that help maintain neuronal polarity.
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电压门控钙通道在神经递质释放点的定位
在突触前活动区,电压门控 Ca2+ 通道(CaVs)介导 Ca2+ 进入神经递质释放。CaVs 是一个庞大的蛋白质家族,不同的亚型在神经元体细胞、树突和轴突上有不同的定位。在此,我们回顾了神经元如何在其活动区建立并维持特定的 CaV 复合物。我们将重点放在货物组装、突触前递送和释放位点系留的分子决定因素上,并讨论了最近确定 CaV 细胞内 C 端关键作用的工作。最后,我们评估了这些机制在不同类型的神经元之间可能存在的差异。有关 CaVs 的研究有助于深入了解有助于维持神经元极性的蛋白质靶向途径。
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来源期刊
Current Opinion in Neurobiology
Current Opinion in Neurobiology 医学-神经科学
CiteScore
11.10
自引率
1.80%
发文量
130
审稿时长
4-8 weeks
期刊介绍: Current Opinion in Neurobiology publishes short annotated reviews by leading experts on recent developments in the field of neurobiology. These experts write short reviews describing recent discoveries in this field (in the past 2-5 years), as well as highlighting select individual papers of particular significance. The journal is thus an important resource allowing researchers and educators to quickly gain an overview and rich understanding of complex and current issues in the field of Neurobiology. The journal takes a unique and valuable approach in focusing each special issue around a topic of scientific and/or societal interest, and then bringing together leading international experts studying that topic, embracing diverse methodologies and perspectives. Journal Content: The journal consists of 6 issues per year, covering 8 recurring topics every other year in the following categories: -Neurobiology of Disease- Neurobiology of Behavior- Cellular Neuroscience- Systems Neuroscience- Developmental Neuroscience- Neurobiology of Learning and Plasticity- Molecular Neuroscience- Computational Neuroscience
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