{"title":"On the targeting of voltage-gated calcium channels to neurotransmitter release sites","authors":"Morven Chin, Pascal S. Kaeser","doi":"10.1016/j.conb.2024.102931","DOIUrl":null,"url":null,"abstract":"<div><div>At the presynaptic active zone, voltage-gated Ca<sup>2+</sup> channels (Ca<sub>V</sub>s) mediate Ca<sup>2+</sup> entry for neurotransmitter release. Ca<sub>V</sub>s are a large family of proteins, and different subtypes have distinct localizations across neuronal somata, dendrites and axons. Here, we review how neurons establish and maintain a specific Ca<sub>V</sub> repertoire at their active zones. We focus on molecular determinants for cargo assembly, presynaptic delivery and release site tethering, and we discuss recent work that has identified key roles of the Ca<sub>V</sub> intracellular C-terminus. Finally, we evaluate how these mechanisms may differ between different types of neurons. Work on Ca<sub>V</sub>s provides insight into the protein targeting pathways that help maintain neuronal polarity.</div></div>","PeriodicalId":10999,"journal":{"name":"Current Opinion in Neurobiology","volume":"89 ","pages":"Article 102931"},"PeriodicalIF":4.8000,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Opinion in Neurobiology","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S095943882400093X","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"NEUROSCIENCES","Score":null,"Total":0}
引用次数: 0
Abstract
At the presynaptic active zone, voltage-gated Ca2+ channels (CaVs) mediate Ca2+ entry for neurotransmitter release. CaVs are a large family of proteins, and different subtypes have distinct localizations across neuronal somata, dendrites and axons. Here, we review how neurons establish and maintain a specific CaV repertoire at their active zones. We focus on molecular determinants for cargo assembly, presynaptic delivery and release site tethering, and we discuss recent work that has identified key roles of the CaV intracellular C-terminus. Finally, we evaluate how these mechanisms may differ between different types of neurons. Work on CaVs provides insight into the protein targeting pathways that help maintain neuronal polarity.
期刊介绍：
Current Opinion in Neurobiology publishes short annotated reviews by leading experts on recent developments in the field of neurobiology. These experts write short reviews describing recent discoveries in this field (in the past 2-5 years), as well as highlighting select individual papers of particular significance.
The journal is thus an important resource allowing researchers and educators to quickly gain an overview and rich understanding of complex and current issues in the field of Neurobiology. The journal takes a unique and valuable approach in focusing each special issue around a topic of scientific and/or societal interest, and then bringing together leading international experts studying that topic, embracing diverse methodologies and perspectives.
Journal Content: The journal consists of 6 issues per year, covering 8 recurring topics every other year in the following categories:
-Neurobiology of Disease-
Neurobiology of Behavior-
Cellular Neuroscience-
Systems Neuroscience-
Developmental Neuroscience-
Neurobiology of Learning and Plasticity-
Molecular Neuroscience-
Computational Neuroscience
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