Karthik Gnanapandithan, Lauren Stemboroski, Abbey Johnston, Maged P. Ghali
{"title":"Distribution and inflammatory potential of hepatitis C virus genotypes in the United States, 2011–2020","authors":"Karthik Gnanapandithan, Lauren Stemboroski, Abbey Johnston, Maged P. Ghali","doi":"10.1002/jgh3.70049","DOIUrl":null,"url":null,"abstract":"<p>HCV is marked by genetic diversity that impacts disease progression and outcome. Using the NHANES data from 266 HCV-infected adults (2011–2020), this study infers that genotype 1a is the most prevalent (60.2%). Genotype 3 was associated with higher transaminase levels, though not statistically significant. These findings suggest a more aggressive phenotype for genotype 3. Despite pan-genotypic treatment guidelines, this underscores the importance of continued HCV genotype surveillance and consideration for genotype-specific treatment and monitoring strategies.\n <figure>\n <div><picture>\n <source></source></picture><p></p>\n </div>\n </figure></p>","PeriodicalId":45861,"journal":{"name":"JGH Open","volume":"8 11","pages":""},"PeriodicalIF":1.7000,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jgh3.70049","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"JGH Open","FirstCategoryId":"1085","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/jgh3.70049","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"GASTROENTEROLOGY & HEPATOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
HCV is marked by genetic diversity that impacts disease progression and outcome. Using the NHANES data from 266 HCV-infected adults (2011–2020), this study infers that genotype 1a is the most prevalent (60.2%). Genotype 3 was associated with higher transaminase levels, though not statistically significant. These findings suggest a more aggressive phenotype for genotype 3. Despite pan-genotypic treatment guidelines, this underscores the importance of continued HCV genotype surveillance and consideration for genotype-specific treatment and monitoring strategies.