Distinct age-related characteristics in patients with irritable bowel syndrome: patient reported outcomes and measures of gut physiology

Joost P. Algera, Amanda Blomsten, Mahrukh Khadija, Kristin Verbeke, Tim Vanuytsel, Jan Tack, Magnus Simrén, Hans Törnblom
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Abstract

Irritable bowel syndrome (IBS) is common among all ages, but the associations between symptoms, gut physiology, and ageing are poorly understood. We aimed to characterize patients of different age by comparing symptom reports and gut physiology measures. This retrospective cohort study included IBS patients that completed questionnaires (severity of (non-) gastrointestinal and psychological symptoms, quality of life) and gut physiology testing (transit time, rectal sensitivity, anorectal manometry, small bowel permeability). We included 1677 IBS patients (females 74%, mean age 39 ± 14 years). Younger age was associated with more severe symptoms and worse quality of life. Ageing affects the physiologic state of the gut; older patients have slower gut transit and have an altered anorectal function. Exploratory analyses suggest that age-related changes in gut sensorimotor function could partially explain the severity of specific gastrointestinal symptoms. Our results underline that age should be taken into consideration in the management of IBS.

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肠易激综合征患者的不同年龄特征:患者报告的结果和肠道生理指标
肠易激综合征(IBS)在各个年龄段都很常见,但人们对其症状、肠道生理机能和衰老之间的关系却知之甚少。我们的目的是通过比较症状报告和肠道生理指标来描述不同年龄段患者的特征。这项回顾性队列研究纳入了完成问卷调查((非)胃肠道症状和心理症状的严重程度、生活质量)和肠道生理测试(转运时间、直肠敏感度、肛门直肠测压、小肠通透性)的肠易激综合征患者。我们共纳入了 1677 名肠易激综合征患者(女性占 74%,平均年龄为 39 ± 14 岁)。年龄越小,症状越严重,生活质量越差。年龄的增长会影响肠道的生理状态;老年患者的肠道转运速度较慢,肛门直肠功能也会发生改变。探索性分析表明,与年龄相关的肠道感觉运动功能变化可以部分解释特定胃肠道症状的严重程度。我们的研究结果强调,在治疗肠易激综合征时应考虑年龄因素。
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