Recent advances in photocatalytic and transition metal-catalyzed synthesis of disulfide compounds.

IF 2.9 3区 化学 Q1 CHEMISTRY, ORGANIC Organic & Biomolecular Chemistry Pub Date : 2024-11-05 DOI:10.1039/d4ob01362j
Jia-Lin Tu
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Abstract

Disulfide bonds are essential in protein folding, cellular redox balance, materials science, and drug development. Despite existing synthetic methods, the efficient and selective synthesis of unsymmetrical disulfides remains challenging. This review highlights innovative approaches in visible light photocatalysis, including decarboxylation, deoxydisulfidation of alcohols, and direct C-H disulfidation, showcasing broad substrate applicability and functional group tolerance under mild conditions. Additionally, it explores transition metal-catalyzed systems with copper, nickel, palladium, chromium, Iridium, Rhodium molybdenum, and scandium, offering effective strategies for unsymmetrical disulfide bond formation and late-stage functionalization of complex molecules through reductive coupling, selective oxidation, and novel insertion reactions.

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光催化和过渡金属催化合成二硫化物的最新进展。
二硫键在蛋白质折叠、细胞氧化还原平衡、材料科学和药物开发中至关重要。尽管已有合成方法,但高效、选择性地合成非对称二硫化物仍具有挑战性。本综述重点介绍了可见光光催化的创新方法,包括脱羧、醇的脱氧二硫化和直接 C-H 二硫化,展示了温和条件下广泛的底物适用性和官能团耐受性。此外,该书还探讨了铜、镍、钯、铬、铱、铑钼和钪等过渡金属催化系统,通过还原偶联、选择性氧化和新型插入反应,为非对称二硫键的形成和复杂分子的后期官能化提供了有效的策略。
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来源期刊
Organic & Biomolecular Chemistry
Organic & Biomolecular Chemistry 化学-有机化学
CiteScore
5.50
自引率
9.40%
发文量
1056
审稿时长
1.3 months
期刊介绍: The international home of synthetic, physical and biomolecular organic chemistry.
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