Microfluidic Synthesis of Magnetic Nanoparticles for Biomedical Applications.

IF 10.7 2区 材料科学 Q1 CHEMISTRY, PHYSICAL Small Methods Pub Date : 2024-11-06 DOI:10.1002/smtd.202401220
Yunru Yu, Changqing Zhang, Xin Yang, Lingyu Sun, Feika Bian
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Abstract

Magnetic nanoparticles have attracted great attention and become promising candidates in the biomedicine field due to their special physicochemical properties. They are generally divided into metallic and non-metallic magnetic nanoparticles, according to their compositions. Both of the two types have shown practical values in biomedicine applications, such as drug delivery, biosensing, bioimaging, and so on. Research efforts are devoted to the improvement of synthesis strategies to achieve magnetic nanoparticles with controllable morphology, diverse composition, active surface, or multiple functions. Taking high repeatability, programmable operation, precise fluid control, and simple device into account, the microfluidics system can expand the production scale and develop magnetic nanoparticles with desired features. This review will first describe different classifications of promising magnetic nanoparticles, followed by the advancements in microfluidic synthesis and the latest biomedical applications of these magnetic nanoparticles. In addition, the challenges and prospects of magnetic nanoparticles in the biomedical field are also discussed.

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用于生物医学应用的磁性纳米粒子的微流体合成。
磁性纳米粒子因其特殊的物理化学性质而备受关注,并成为生物医学领域大有可为的候选物质。根据成分,磁性纳米粒子一般分为金属磁性纳米粒子和非金属磁性纳米粒子。这两种类型在生物医学应用中都显示出了实用价值,如药物输送、生物传感、生物成像等。研究人员致力于改进合成策略,以获得形态可控、成分多样、表面活性或具有多种功能的磁性纳米粒子。考虑到高重复性、可编程操作、精确的流体控制和简单的设备,微流控系统可以扩大生产规模,并开发出具有所需功能的磁性纳米粒子。本综述将首先介绍有前景的磁性纳米粒子的不同分类,然后介绍微流控合成的进展以及这些磁性纳米粒子的最新生物医学应用。此外,还讨论了磁性纳米粒子在生物医学领域面临的挑战和前景。
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来源期刊
Small Methods
Small Methods Materials Science-General Materials Science
CiteScore
17.40
自引率
1.60%
发文量
347
期刊介绍: Small Methods is a multidisciplinary journal that publishes groundbreaking research on methods relevant to nano- and microscale research. It welcomes contributions from the fields of materials science, biomedical science, chemistry, and physics, showcasing the latest advancements in experimental techniques. With a notable 2022 Impact Factor of 12.4 (Journal Citation Reports, Clarivate Analytics, 2023), Small Methods is recognized for its significant impact on the scientific community. The online ISSN for Small Methods is 2366-9608.
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