Surgical opioid prescription and the risk of opioid initiation among opioid-naive households

IF 2.7 3区医学 Q1 SURGERY American journal of surgery Pub Date : 2024-10-18 DOI:10.1016/j.amjsurg.2024.116029

Mujtaba Khalil, Selamawit Woldesenbet, Muhammad Musaab Munir, Zayed Rashid, Muhammad Muntazir Mehdi Khan, Abdullah Altaf, Vennila Padmanaban, Mary Dillhoff, Mark Arnold, Timothy M. Pawlik

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Abstract

Background

We sought to investigate the association between surgical opioid prescriptions and the risk of opioid initiation among opioid-naive spouses.

Methods

Patients who underwent surgery for breast or gastrointestinal cancer were identified from the IBM Marketscan database. Multivariable regression analysis was performed to examine the association between surgical opioid prescription and opioid initiation among opioid-naïve patient spouses.

Results

Among the 9365 individuals included in the analytic cohort, 77.9 % (n = 7300) filled a perioperative opioid prescription. Of note, spouses of patients who received a surgical opioid prescription (6.7 % vs. 4.5 %; p < 0.001) were more likely to begin using opioids. On multivariable analysis, surgical opioid prescription was associated with 61 % (1.61, 95%CI 1.28–2.03) higher odds of opioid initiation among opioid-naïve spouses.

Conclusion

Surgical opioid prescriptions are associated with an increased risk of opioid initiation among opioid-naive spouses. These findings underscore the importance of counseling on safe opioid use, storage, and disposal for the family.

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手术阿片类药物处方与未服用阿片类药物家庭开始服用阿片类药物的风险。

背景：我们试图研究手术阿片类药物处方与未服用阿片类药物的配偶开始服用阿片类药物的风险之间的关联：方法：我们从 IBM Marketscan 数据库中找到了接受乳腺癌或胃肠道癌症手术的患者。对手术阿片类药物处方与阿片类药物无效患者配偶开始使用阿片类药物之间的关系进行了多变量回归分析：在纳入分析队列的 9365 人中，77.9%（n = 7300）的人开具了围手术期阿片类药物处方。值得注意的是，接受过阿片类药物手术处方的患者配偶（6.7% 对 4.5%；P 结论：阿片类药物手术处方的使用率与未接受过阿片类药物手术的患者配偶的使用率有很大差异：手术阿片类药物处方与未服用阿片类药物的配偶开始服用阿片类药物的风险增加有关。这些发现强调了为家人提供阿片类药物安全使用、储存和处置咨询的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

American journal of surgery 医学-外科

CiteScore

5.00

自引率

6.70%

发文量

570

审稿时长

56 days

期刊介绍： The American Journal of Surgery® is a peer-reviewed journal designed for the general surgeon who performs abdominal, cancer, vascular, head and neck, breast, colorectal, and other forms of surgery. AJS is the official journal of 7 major surgical societies* and publishes their official papers as well as independently submitted clinical studies, editorials, reviews, brief reports, correspondence and book reviews.