Clinical evaluation of combined autologous Platelet-Rich Plasma and Volume-Controlled Ozone Therapy in Facial Rejuvenation: A randomized controlled Pilot Study.

IF 1.1 4区 综合性期刊 Q3 MULTIDISCIPLINARY SCIENCES Anais da Academia Brasileira de Ciencias Pub Date : 2024-11-04 eCollection Date: 2024-01-01 DOI:10.1590/0001-3765202420240402
Carla Camargo, Carla Tim, Cintia Cristina S Martignago, Ana Claudia M Renno, Paula Cassanelli E Silva, Ana Laura M DE Andrade, Jynani Pichara, Eliana Claudia P Morato, José Ricardo DE Souza, Lívia Assis
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Abstract

Platelet rich plasma and ozone therapy have been suggested in the clinical setting as promising and adjuvant therapies for managing the symptoms related to the facial aging. However, there is a lack of evidence about the effects of combining both therapies on rejuvenation. Thus, the aim of the present study was to evaluate and to compare the safety and efficacy of both therapies in facial aging. A single-center prospective pilot study was conducted. Female participants, aged 40 to 60 years, were randomized into 2 groups: participants received the platelet rich plasma treatment (PRP); participants received the therapy with platelet rich plasma associated with ozone therapy (PRPOT). Interventions were performed using the facial intradermal technique in 42 pre-established points, for 4 sessions with an interval of 15 days between them. After analyses performed using photographic records, assessment of frontal, periorbital, nasolabial and marionette wrinkles (Wrinkle Assessment Scale), self-esteem assessment (Brazilian Version of Rosenberg's Self-Esteem Scale) and assessment of patient satisfaction (FACE-Q) can be suggested that the platelet rich plasma protocol performed in the present study, as well as its association with volume-controlled ozone therapy, proved to be safe and potentially promising modalities in the treatment of facial aging.

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自体富血小板血浆和容量控制臭氧疗法联合用于面部年轻化的临床评估:随机对照试验研究。
在临床上,富血小板血浆疗法和臭氧疗法被认为是治疗面部衰老相关症状的前景广阔的辅助疗法。然而,目前还没有证据表明将这两种疗法结合在一起会对年轻化产生影响。因此,本研究旨在评估和比较两种疗法对面部衰老的安全性和有效性。本研究是一项单中心前瞻性试验研究。年龄在 40 至 60 岁之间的女性参与者被随机分为两组:一组接受富血小板血浆疗法(PRP),另一组接受富血小板血浆联合臭氧疗法(PRPOT)。治疗采用面部皮内技术,在 42 个预先确定的穴位上进行,共进行 4 次,每次间隔 15 天。经过对照片记录、额头皱纹、眶周皱纹、鼻唇沟皱纹和牵索状皱纹评估(皱纹评估量表)、自尊评估(巴西版罗森伯格自尊量表)和患者满意度评估(FACE-Q)进行分析后,可以认为本研究中采用的富血小板血浆疗法及其与容量控制臭氧疗法的结合被证明是治疗面部衰老的安全且有潜力的方法。
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来源期刊
Anais da Academia Brasileira de Ciencias
Anais da Academia Brasileira de Ciencias 综合性期刊-综合性期刊
CiteScore
2.20
自引率
0.00%
发文量
347
审稿时长
1 months
期刊介绍: The Brazilian Academy of Sciences (BAS) publishes its journal, Annals of the Brazilian Academy of Sciences (AABC, in its Brazilianportuguese acronym ), every 3 months, being the oldest journal in Brazil with conkinuous distribukion, daking back to 1929. This scienkihic journal aims to publish the advances in scienkihic research from both Brazilian and foreigner scienkists, who work in the main research centers in the whole world, always looking for excellence. Essenkially a mulkidisciplinary journal, the AABC cover, with both reviews and original researches, the diverse areas represented in the Academy, such as Biology, Physics, Biomedical Sciences, Chemistry, Agrarian Sciences, Engineering, Mathemakics, Social, Health and Earth Sciences.
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