Effectiveness of phentolamine mesylate, vibration and photobiomodulation in reducing pain and the reversal of local anesthesia: A systematic review.

IF 2.1 4区 医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL Advances in Clinical and Experimental Medicine Pub Date : 2024-11-06 DOI:10.17219/acem/190202
Aneta Olszewska, Dominika Forszt, Aleksandra Szymczak, Natalie Górna, Tomasz Gedrange, Agata Czajka-Jakubowska, Jacek Matys
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Abstract

Background: Dental anesthesia administration often triggers unpleasant sensations, particularly needle injection-related pain, which can evoke fear among patients, especially in the pediatric population. Vibration and low-level laser therapy (LLLT) have been extensively studied as potential methods for alleviating pain. Additionally, phentolamine mesylate (PM) has shown promise in reducing the duration of anesthesia. From a clinical perspective, inadequate control over the persistence of the anesthetic effect may lead to complications associated with its prolonged duration, such as self-injuries or functional impairments.

Objectives: This review aimed to systematically summarize and compare methods of alleviating pain during local anesthesia and reducing its duration.

Material and methods: In November 2023, an electronic search was systematically conducted across PubMed, Web of Science, and Scopus databases using keywords (pain) AND (anesthesia) AND ((phentolamine) or (vibration) or (LLLT) OR (PBM)). The initial pool consisted of 495 records, from which 241 duplicates were eliminated. After careful examination of the remaining articles, 40 were included. The study adhered to the PRISMA guidelines.

Results: Most studies reported beneficial effects of LLLT and vibration; however, some did not corroborate these findings. Four studies had inconclusive results. Regarding anesthesia duration involving PM and LLLT, the majority of studies exhibited notable reductions, although no significant differences were revealed in 1 study.

Conclusion: Vibration and LLLT appear to be advantageous methods in alleviating pain associated with local anesthesia administration. Phentolamine mesylate and LLLT are efficient in reversing local anesthesia.

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甲磺酸酚妥拉明、振动和光生物调节在减轻疼痛和逆转局部麻醉方面的效果:系统综述。
背景:牙科麻醉常常会引发不愉快的感觉,尤其是与针头注射相关的疼痛,这会引起患者的恐惧,尤其是在儿童群体中。振动和低强度激光疗法(LLLT)作为缓解疼痛的潜在方法已被广泛研究。此外,甲磺酸酚妥拉明(PM)在缩短麻醉时间方面也显示出良好的前景。从临床角度来看,如果对麻醉效果的持续时间控制不当,可能会导致与麻醉持续时间过长有关的并发症,如自伤或功能障碍:本综述旨在系统总结和比较局麻期间减轻疼痛和缩短疼痛持续时间的方法:2023 年 11 月,使用关键词(疼痛)和(麻醉)和(酚妥拉明)或(振动)或(LLLT)或(PBM)在 PubMed、Web of Science 和 Scopus 数据库中进行了系统的电子检索。最初的资料库共有 495 条记录,其中剔除了 241 条重复记录。对剩余文章进行仔细检查后,纳入了 40 篇文章。研究遵循了 PRISMA 指南:大多数研究报告了 LLLT 和振动的有益效果,但有些研究并未证实这些结果。有四项研究没有得出结论。在涉及 PM 和 LLLT 的麻醉持续时间方面,大多数研究显示麻醉持续时间明显缩短,但有一项研究未发现显著差异:结论:振动和 LLLT 似乎是减轻与局部麻醉相关的疼痛的有利方法。甲磺酸酚妥拉明和 LLLT 可有效逆转局部麻醉。
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来源期刊
Advances in Clinical and Experimental Medicine
Advances in Clinical and Experimental Medicine MEDICINE, RESEARCH & EXPERIMENTAL-
CiteScore
3.70
自引率
4.80%
发文量
153
审稿时长
6-12 weeks
期刊介绍: Advances in Clinical and Experimental Medicine has been published by the Wroclaw Medical University since 1992. Establishing the medical journal was the idea of Prof. Bogumił Halawa, Chair of the Department of Cardiology, and was fully supported by the Rector of Wroclaw Medical University, Prof. Zbigniew Knapik. Prof. Halawa was also the first editor-in-chief, between 1992-1997. The journal, then entitled "Postępy Medycyny Klinicznej i Doświadczalnej", appeared quarterly. Prof. Leszek Paradowski was editor-in-chief from 1997-1999. In 1998 he initiated alterations in the profile and cover design of the journal which were accepted by the Editorial Board. The title was changed to Advances in Clinical and Experimental Medicine. Articles in English were welcomed. A number of outstanding representatives of medical science from Poland and abroad were invited to participate in the newly established International Editorial Staff. Prof. Antonina Harłozińska-Szmyrka was editor-in-chief in years 2000-2005, in years 2006-2007 once again prof. Leszek Paradowski and prof. Maria Podolak-Dawidziak was editor-in-chief in years 2008-2016. Since 2017 the editor-in chief is prof. Maciej Bagłaj. Since July 2005, original papers have been published only in English. Case reports are no longer accepted. The manuscripts are reviewed by two independent reviewers and a statistical reviewer, and English texts are proofread by a native speaker. The journal has been indexed in several databases: Scopus, Ulrich’sTM International Periodicals Directory, Index Copernicus and since 2007 in Thomson Reuters databases: Science Citation Index Expanded i Journal Citation Reports/Science Edition. In 2010 the journal obtained Impact Factor which is now 1.179 pts. Articles published in the journal are worth 15 points among Polish journals according to the Polish Committee for Scientific Research and 169.43 points according to the Index Copernicus. Since November 7, 2012, Advances in Clinical and Experimental Medicine has been indexed and included in National Library of Medicine’s MEDLINE database. English abstracts printed in the journal are included and searchable using PubMed http://www.ncbi.nlm.nih.gov/pubmed.
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