Unlocking the therapeutic potential and personalized therapy of testosterone: a comprehensive review.

Q2 Pharmacology, Toxicology and Pharmaceutics Drug metabolism and personalized therapy Pub Date : 2024-11-06 DOI:10.1515/dmpt-2024-0035

Aditya V Reddy, Ramasamy Kesavan, Rajendran Priyadharsini, Reka Deva

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Abstract

Introduction: Testosterone, the primary male sex hormone, orchestrates various physiological processes including sex differentiation, development of male characteristics, sperm production, and fertility. Its synthesis primarily occurs in Leydig cells within the testes, with smaller contributions from the ovaries and adrenal glands, all derived from cholesterol. Current therapeutic use of testosterone is mainly confined to treating hypergonadotropic hypogonadism, with limited off-label usage for augmenting muscle growth.

Content: This review delves into numerous studies investigating testosterone's therapeutic potential across various medical conditions as depicted in the figure given below.

Summary: Of all the studies in this review, which show a positive therapeutic result by using testosterone, the most promising areas of potential usage of testosterone are anxiety and diabetes mellitus, followed by obesity and depression.

Outlook: By the medium if this study, we want to not only enlist the various potential therapeutic uses of testosterone, but also promote a optimal hormonal balance, which can lead to prevention and/or better treatment outcomes for the mentioned diseases.

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挖掘睾酮的治疗潜力和个性化疗法：全面综述。

简介睾酮是男性的主要性激素，它协调着各种生理过程，包括性别分化、男性特征的发育、精子生成和生育。睾酮主要由睾丸内的雷德细胞合成，卵巢和肾上腺的合成量较少，均来自胆固醇。目前，睾酮的治疗用途主要局限于治疗促性腺激素分泌过多性性腺功能减退症，在标签外用于促进肌肉生长的用途有限：本综述深入研究了睾酮在各种病症中的治疗潜力，如下图所示。摘要：本综述中的所有研究都显示，使用睾酮能产生积极的治疗效果，其中最有潜力使用睾酮的领域是焦虑症和糖尿病，其次是肥胖症和抑郁症：通过这项研究，我们不仅要列出睾酮的各种潜在治疗用途，还要促进荷尔蒙的最佳平衡，从而预防和/或改善上述疾病的治疗效果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Drug metabolism and personalized therapy Pharmacology, Toxicology and Pharmaceutics-Pharmacology, Toxicology and Pharmaceutics (all)

CiteScore

2.30

自引率

0.00%

发文量

期刊介绍： Drug Metabolism and Personalized Therapy (DMPT) is a peer-reviewed journal, and is abstracted/indexed in relevant major Abstracting Services. It provides up-to-date research articles, reviews and opinion papers in the wide field of drug metabolism research, covering established, new and potential drugs, environmentally toxic chemicals, the mechanisms by which drugs may interact with each other and with biological systems, and the pharmacological and toxicological consequences of these interactions and drug metabolism and excretion. Topics: drug metabolizing enzymes, pharmacogenetics and pharmacogenomics, biochemical pharmacology, molecular pathology, clinical pharmacology, pharmacokinetics and drug-drug interactions, immunopharmacology, neuropsychopharmacology.