Diabetic Cardiomyopathy: An Update on Emerging Pathological Mechanisms.

IF 2.4 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS Current Cardiology Reviews Pub Date : 2024-11-04 DOI:10.2174/011573403X331870241025094307
Chirag Kakkar, Veerta Sharma, Ashi Mannan, Gaurav Gupta, Sachin Singh, Puneet Kumar, Kamal Dua, Amarjot Kaur, Shareen Singh, Sonia Dhiman, Thakur Gurjeet Singh
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Abstract

Diabetic Cardiomyopathy (DCM) is a notable consequence of diabetes mellitus, distinguished by cardiac dysfunction that occurs separately from coronary artery disease or hypertension. A recent study has revealed an intricate interaction of pathogenic processes that contribute to DCM. Important aspects involve the dysregulation of glucose metabolism, resulting in heightened oxidative stress and impaired mitochondrial function. In addition, persistent high blood sugar levels stimulate inflammatory pathways, which contribute to the development of heart fibrosis and remodelling. Additionally, changes in the way calcium is managed and the presence of insulin resistance are crucial factors in the formation and advancement of DCM. This may be due to the involvement of many molecular mechanistic pathways such as NLRP3, NF- κB, PKC, and MAPK with their downstream associated signaling pathways. Gaining a comprehensive understanding of these newly identified pathogenic pathways is crucial in order to design precise therapy approaches that can enhance the results for individuals suffering from diabetes. In addition, this review offers an in-depth review of not just pathogenic pathways and molecular mechanistic pathways but also diagnostic methods, treatment options, and clinical trials.

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糖尿病心肌病:最新病理机制。
糖尿病心肌病(DCM)是糖尿病的一个显著后果,其心脏功能障碍与冠状动脉疾病或高血压不同。最近的一项研究揭示了导致 DCM 的致病过程之间错综复杂的相互作用。其中重要的是葡萄糖代谢失调,导致氧化应激增加和线粒体功能受损。此外,持续的高血糖水平会刺激炎症途径,导致心脏纤维化和重塑。此外,钙管理方式的改变和胰岛素抵抗的存在也是 DCM 形成和发展的关键因素。这可能是由于许多分子机制途径的参与,如 NLRP3、NF- κB、PKC 和 MAPK 及其下游相关信号途径。全面了解这些新发现的致病通路对于设计精确的治疗方法、提高糖尿病患者的治疗效果至关重要。此外,本综述不仅对致病途径和分子机制途径进行了深入评述,还对诊断方法、治疗方案和临床试验进行了评述。
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来源期刊
Current Cardiology Reviews
Current Cardiology Reviews CARDIAC & CARDIOVASCULAR SYSTEMS-
CiteScore
3.70
自引率
10.50%
发文量
117
期刊介绍: Current Cardiology Reviews publishes frontier reviews of high quality on all the latest advances on the practical and clinical approach to the diagnosis and treatment of cardiovascular disease. All relevant areas are covered by the journal including arrhythmia, congestive heart failure, cardiomyopathy, congenital heart disease, drugs, methodology, pacing, and preventive cardiology. The journal is essential reading for all researchers and clinicians in cardiology.
期刊最新文献
Elevated Perspectives: Unraveling Cardiovascular Dynamics in High-Altitude Realms. Diabetic Cardiomyopathy: An Update on Emerging Pathological Mechanisms. Heart Rate Variability and Heart Failure with Reduced Ejection Fraction: A Systematic Review of Literature. Comprehensive Review of Coronary Artery Anatomy Relevant to Cardiac Surgery. Unveiling the Complexities: Exploring Mechanisms of Anthracycline-Induced Cardiotoxicity.
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