A novel non-contrast agent-enhanced 3D whole-heart magnetic resonance sequence for congenital heart disease patients: the REACT Study.

IF 2.1 3区 医学 Q2 PEDIATRICS Pediatric Radiology Pub Date : 2024-11-06 DOI:10.1007/s00247-024-06087-0
Sukran Erdem, Gerald F Greil, M Tarique Hussain, Qing Zou
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引用次数: 0

Abstract

Background: The three-dimensional balanced-steady-state-free-precession (3D bSSFP) whole-heart (WH) technique has long been used to depict cardiac morphology in congenital heart disease (CHD) but is prone to banding artifacts. The Relaxation Enhanced Angiography without Contrast and Triggering (REACT) sequence is an alternative method that is resistant to off-resonance effects.

Objective: To evaluate cardiac structures and great vessels in CHD patients using 3D WH REACT sequence and compare it to 3D WH bSSFP sequence.

Materials and methods: This study was approved by the Institutional Review Board. Thirty CHD patients were prospectively enrolled. Contrast-to-noise ratio (CNR), image quality, and cross-sectional area (CSA) were analyzed. Categorical data were compared with a Wilcoxon signed-rank test and normally distributed variables with a t-test.

Results: Thirty patients (16 females) participated in this study (median age 17, range 5 months to 52 years). REACT showed higher CNR in all pulmonary veins (all P<0.05), while 3D bSSFP had higher CNR in the right ventricle (P<0.001) and right pulmonary artery, (P=0.04). Image quality favored 3D bSSFP in the right atrium and ventricle (both P<0.001), main pulmonary artery (P=0.02), and coronary arteries (left: P<0.001, right: P=0.01). REACT outperformed 3D bSSFP for the pulmonary veins (all P<0.05) from image quality perspective. CSA measurements were not significantly different between REACT and 3D bSSFP (all P≥0.05).

Conclusion: The REACT method is associated with improved image quality and CNR for pulmonary veins, with CSA measurements concordant with 3D bSSFP in CHD patients, while bSSFP shows better performance for imaging cardiac chambers and coronary arteries.

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针对先天性心脏病患者的新型非造影剂增强三维全心磁共振序列:REACT 研究。
背景:长期以来,三维平衡稳态自由预处理(3D bSSFP)全心(WH)技术一直用于描述先天性心脏病(CHD)的心脏形态,但容易产生带状伪影。无对比度和触发的弛豫增强血管造影(REACT)序列是一种可替代的方法,它能抵御非共振效应:使用三维 WH REACT 序列评估心脏病患者的心脏结构和大血管,并将其与三维 WH bSSFP 序列进行比较:本研究已获得机构审查委员会批准。材料和方法:本研究获得了机构审查委员会的批准。对对比-噪声比(CNR)、图像质量和横截面积(CSA)进行了分析。分类数据的比较采用 Wilcoxon 符号秩检验,正态分布变量的比较采用 t 检验:30名患者(16名女性)参加了此次研究(中位年龄17岁,5个月至52岁)。REACT在所有肺静脉(所有PC)中都显示出更高的CNR:REACT方法提高了肺静脉的图像质量和CNR,CSA测量结果与CHD患者的3D bSSFP一致,而bSSFP在心腔和冠状动脉成像方面表现更好。
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来源期刊
Pediatric Radiology
Pediatric Radiology 医学-核医学
CiteScore
4.40
自引率
17.40%
发文量
300
审稿时长
3-6 weeks
期刊介绍: Official Journal of the European Society of Pediatric Radiology, the Society for Pediatric Radiology and the Asian and Oceanic Society for Pediatric Radiology Pediatric Radiology informs its readers of new findings and progress in all areas of pediatric imaging and in related fields. This is achieved by a blend of original papers, complemented by reviews that set out the present state of knowledge in a particular area of the specialty or summarize specific topics in which discussion has led to clear conclusions. Advances in technology, methodology, apparatus and auxiliary equipment are presented, and modifications of standard techniques are described. Manuscripts submitted for publication must contain a statement to the effect that all human studies have been reviewed by the appropriate ethics committee and have therefore been performed in accordance with the ethical standards laid down in an appropriate version of the 1964 Declaration of Helsinki. It should also be stated clearly in the text that all persons gave their informed consent prior to their inclusion in the study. Details that might disclose the identity of the subjects under study should be omitted.
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