β-Hydroxybutyrate and Citrate Synthase as Potential Diagnostic Biomarkers in Aging-Related Atrial Fibrillation.

IF 2.4 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS Journal of Cardiovascular Translational Research Pub Date : 2024-11-05 DOI:10.1007/s12265-024-10569-9

Jia-Kang He, Xiao-Xiao Jiang, Shi-Yu Dai, Xiao-Han, Qian-Qiu Zhu, Jie-Yang, Yun-Long Zhang, Xiao-Hong Yu

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Abstract

The incidence of atrial fibrillation (AF) increases with age; however, the precise mechanisms by which aging elevates AF risk and the effective biomarkers for managing AF in elderly patients remain unclear. We analyzed plasma samples from 100 elderly AF patients, 100 young and 100 elderly patients without atrial fibrillation (NAF), along with left atrial tissues obtained from both AF and NAF patients following valve replacement. Our findings indicate reduced levels of β-OHB and citrate synthase (CS) activity in elderly AF patients compared to their NAF counterparts. Statistical analysis revealed a protective association between β-OHB and CS activity concerning the occurrence of elderly AF. Furthermore, atrial tissues from elderly AF patients exhibited mitochondrial dysfunction, structural remodeling, and low-voltage areas. These results suggest that dysregulation of β-OHB levels and CS activity may contribute to aging-related AF by affecting mitochondrial function and atrial remodeling, highlighting their potential as diagnostic biomarkers for this condition.

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β-羟丁酸和柠檬酸合成酶作为衰老相关心房颤动的潜在诊断生物标志物

心房颤动（房颤）的发病率随着年龄的增长而增加；然而，衰老增加房颤风险的确切机制以及控制老年患者房颤的有效生物标志物仍不清楚。我们分析了 100 名老年房颤患者、100 名无房颤（NAF）的年轻患者和 100 名老年患者的血浆样本，以及瓣膜置换术后从房颤和无房颤患者身上获得的左心房组织。我们的研究结果表明，与非房颤患者相比，老年房颤患者体内的β-OHB水平和柠檬酸合成酶（CS）活性降低。统计分析显示，β-OHB 和 CS 活性对老年房颤的发生具有保护作用。此外，老年房颤患者的心房组织表现出线粒体功能障碍、结构重塑和低电压区。这些结果表明，β-OHB水平和CS活性的失调可能会影响线粒体功能和心房重塑，从而导致与衰老相关的房颤，凸显了它们作为房颤诊断生物标志物的潜力。

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来源期刊

Journal of Cardiovascular Translational Research CARDIAC & CARDIOVASCULAR SYSTEMS-MEDICINE, RESEARCH & EXPERIMENTAL

CiteScore

6.10

自引率

2.90%

发文量

148

审稿时长

6-12 weeks

期刊介绍： Journal of Cardiovascular Translational Research (JCTR) is a premier journal in cardiovascular translational research. JCTR is the journal of choice for authors seeking the broadest audience for emerging technologies, therapies and diagnostics, pre-clinical research, and first-in-man clinical trials. JCTR''s intent is to provide a forum for critical evaluation of the novel cardiovascular science, to showcase important and clinically relevant aspects of the new research, as well as to discuss the impediments that may need to be overcome during the translation to patient care.