Yingli Wang, Yalin Jiang, Meiling Xie, Bin Qi, Kunpeng Pu, Wenjie Du, Qingqing Zhang, Mengmeng Ma, Ziyong Chen, Yongxia Guo, Hui Qian, Kaiqin Wang, Tulei Tian, Lin Fu, Xiaofei Zhang
{"title":"Cross-Sectional and Longitudinal Associations of Serum LRG1 with Severity and Prognosis Among Adult Community-Acquired Pneumonia Patients.","authors":"Yingli Wang, Yalin Jiang, Meiling Xie, Bin Qi, Kunpeng Pu, Wenjie Du, Qingqing Zhang, Mengmeng Ma, Ziyong Chen, Yongxia Guo, Hui Qian, Kaiqin Wang, Tulei Tian, Lin Fu, Xiaofei Zhang","doi":"10.2147/JIR.S485932","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Leucine-rich α-2 glycoprotein 1 (LRG1) is associated with various inflammatory lung diseases. Nevertheless, the connection between LRG1 and adult community-acquired pneumonia (CAP) individuals was still not well understood. Through a prospective cohort study, the correlations of serum LRG1 with severity and prognosis were evaluated in CAP patients.</p><p><strong>Methods: </strong>The study encompassed 327 patients who received the diagnosis of CAP. We collected fasting venous blood and clinical features. Serum LRG1 was detected by ELISA. CAP severity was assessed using various scoring systems. The prognostic outcomes were observed through follow-up visits.</p><p><strong>Results: </strong>The level of serum LRG1 at admission was gradually increased with CAP severity scores. Serum LRG1 level shown positive associations with inflammatory indices, including C-reactive protein (CRP), procalcitonin (PCT), and interleukin-6 (IL-6). Linear and logistic regression analyses suggested that serum LRG1 at admission was positively associated with severity scores and the risk of death in CAP patients. Serum LRG1 in combination with CAP severity scores significantly increased the predictive powers for severity and death compared with single serum LRG1 or severity scores.</p><p><strong>Conclusion: </strong>The study revealed positive connections of serum LRG1 levels with severity and poor prognosis in CAP patients, suggesting LRG1 partakes into the physiological processes of CAP. Serum LRG1 may be regarded as a potential biomarker in predicting the severity and death among CAP patients.</p>","PeriodicalId":16107,"journal":{"name":"Journal of Inflammation Research","volume":"17 ","pages":"7951-7962"},"PeriodicalIF":4.2000,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11537034/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Inflammation Research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.2147/JIR.S485932","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"IMMUNOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Background: Leucine-rich α-2 glycoprotein 1 (LRG1) is associated with various inflammatory lung diseases. Nevertheless, the connection between LRG1 and adult community-acquired pneumonia (CAP) individuals was still not well understood. Through a prospective cohort study, the correlations of serum LRG1 with severity and prognosis were evaluated in CAP patients.
Methods: The study encompassed 327 patients who received the diagnosis of CAP. We collected fasting venous blood and clinical features. Serum LRG1 was detected by ELISA. CAP severity was assessed using various scoring systems. The prognostic outcomes were observed through follow-up visits.
Results: The level of serum LRG1 at admission was gradually increased with CAP severity scores. Serum LRG1 level shown positive associations with inflammatory indices, including C-reactive protein (CRP), procalcitonin (PCT), and interleukin-6 (IL-6). Linear and logistic regression analyses suggested that serum LRG1 at admission was positively associated with severity scores and the risk of death in CAP patients. Serum LRG1 in combination with CAP severity scores significantly increased the predictive powers for severity and death compared with single serum LRG1 or severity scores.
Conclusion: The study revealed positive connections of serum LRG1 levels with severity and poor prognosis in CAP patients, suggesting LRG1 partakes into the physiological processes of CAP. Serum LRG1 may be regarded as a potential biomarker in predicting the severity and death among CAP patients.
背景:富亮氨酸 α-2 糖蛋白 1(LRG1)与多种肺部炎症性疾病有关。然而,人们对 LRG1 与成人社区获得性肺炎(CAP)之间的关系仍不甚了解。通过一项前瞻性队列研究,对 CAP 患者血清 LRG1 与病情严重程度和预后的相关性进行了评估:研究涵盖了 327 名确诊为 CAP 的患者。我们收集了空腹静脉血和临床特征。通过 ELISA 检测血清 LRG1。使用各种评分系统评估 CAP 的严重程度。通过随访观察预后结果:结果:入院时血清 LRG1 水平随 CAP 严重程度评分逐渐升高。血清 LRG1 水平与炎症指数(包括 C 反应蛋白(CRP)、降钙素原(PCT)和白细胞介素-6(IL-6))呈正相关。线性和逻辑回归分析表明,入院时的血清 LRG1 与 CAP 患者的严重程度评分和死亡风险呈正相关。与单一血清 LRG1 或严重程度评分相比,血清 LRG1 与 CAP 严重程度评分相结合可显著提高对严重程度和死亡的预测能力:研究显示,血清 LRG1 水平与 CAP 患者的严重程度和不良预后呈正相关,表明 LRG1 参与了 CAP 的生理过程。血清 LRG1 可被视为预测 CAP 患者病情严重程度和死亡的潜在生物标志物。
期刊介绍:
An international, peer-reviewed, open access, online journal that welcomes laboratory and clinical findings on the molecular basis, cell biology and pharmacology of inflammation.