Norwegian and Swedish value sets for the EORTC QLU-C10D utility instrument.

IF 3.3 3区 医学 Q1 HEALTH CARE SCIENCES & SERVICES Quality of Life Research Pub Date : 2024-11-05 DOI:10.1007/s11136-024-03824-8
Gudrun Rohde, Jens Lehmann, Micha J Pilz, Leslye Rojas-Concha, Bernhard Holzner, Madeleine T King, Richard Norman, Georg Kemmler
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Abstract

Purpose: This study aimed to develop utility weights for the European Organization for Research and Treatment of Cancer (EORTC) QLU-C10D, a cancer-specific utility instrument, tailored to the Norwegian and Swedish populations. The utility weights are intended for use in the specific welfare contexts of Norway and Sweden to support more precise healthcare decision-making in cancer treatment and care.

Methods: This cross-sectional study included 1019 Norwegian and 1048 Swedish participants representative in age and gender of the two general populations. Participants completed a discrete choice experiment involving 960 choice sets, each consisting of two EORTC QLU-C10D health states described by the instrument's domains and the duration of each state. Utility weights were calculated using generalized estimation equation models, and non-monotonic levels were merged to ensure consistent valuation.

Results: In the Norwegian participants, the largest utility decrements were seen for the domain of physical functioning (decrement of - 0.263 for highest level "very much"), followed by pain (decrement - 0.205 for level "very much") and role functioning (- 0.139). Among the cancer-specific domains, nausea had the largest utility decrement (- 0.124). In the Swedish participants, the largest utility decrements were also observed for physical functioning (- 0.207 for the response "very much"), followed by pain (- 0.139), role functioning (- 0.133), and nausea (- 0.119). Emotional functioning also exhibited a sizable utility decrement (- 0.115).

Conclusion: This study provides the first set of utility weights for the EORTC QLU-C10D specific to Norway and Sweden, reflecting the unique health preferences of these populations. The generated utility decrements can inform cost-utility analyses and optimize resource allocation in cancer care within the Norwegian and Swedish healthcare systems.

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用于 EORTC QLU-C10D 实用仪器的挪威语和瑞典语数值集。
目的:本研究旨在为欧洲癌症研究和治疗组织(EORTC)的QLU-C10D癌症专用效用工具开发适合挪威和瑞典人口的效用权重。效用权重旨在用于挪威和瑞典的特定福利环境,以支持在癌症治疗和护理方面做出更精确的医疗决策:这项横断面研究包括1019名挪威参与者和1048名瑞典参与者,他们的年龄和性别在两国人口中均具有代表性。参与者完成了一项离散选择实验,其中包括960个选择集,每个选择集由两个EORTC QLU-C10D健康状态组成,这两个健康状态由该工具的领域和每个状态的持续时间来描述。使用广义估计方程模型计算效用权重,并合并非单调水平以确保估值的一致性:在挪威参与者中,效用下降幅度最大的是身体功能领域(最高级别为 "非常",效用下降幅度为-0.263),其次是疼痛(最高级别为 "非常",效用下降幅度为-0.205)和角色功能(-0.139)。在癌症特定领域中,恶心的效用下降幅度最大(- 0.124)。在瑞典受试者中,身体功能的效用下降幅度最大(- 0.207 表示 "非常"),其次是疼痛(- 0.139)、角色功能(- 0.133)和恶心(- 0.119)。情绪功能也出现了相当大的效用下降(- 0.115):本研究为EORTC QLU-C10D提供了第一套针对挪威和瑞典的效用权重,反映了这些国家人口独特的健康偏好。生成的效用递减可为成本效用分析提供信息,并优化挪威和瑞典医疗保健系统中癌症治疗的资源分配。
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来源期刊
Quality of Life Research
Quality of Life Research 医学-公共卫生、环境卫生与职业卫生
CiteScore
6.50
自引率
8.60%
发文量
224
审稿时长
3-8 weeks
期刊介绍: Quality of Life Research is an international, multidisciplinary journal devoted to the rapid communication of original research, theoretical articles and methodological reports related to the field of quality of life, in all the health sciences. The journal also offers editorials, literature, book and software reviews, correspondence and abstracts of conferences. Quality of life has become a prominent issue in biometry, philosophy, social science, clinical medicine, health services and outcomes research. The journal''s scope reflects the wide application of quality of life assessment and research in the biological and social sciences. All original work is subject to peer review for originality, scientific quality and relevance to a broad readership. This is an official journal of the International Society of Quality of Life Research.
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