Moritz Blum, Karen McKendrick, Laura P Gelfman, Nathan E Goldstein
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引用次数: 0
Abstract
Background: Quality of life (QOL) and functional status are two key outcomes for patients with advanced heart failure (HF). We examined the association of eleven symptoms with QOL and functional status impairment in patients with advanced HF.
Methods and results: This was a retrospective analysis of baseline data from a multi-center, cluster-randomized controlled trial (NCT01459744) which enrolled patients with an implanted cardioverter-defibrillator and advanced HF at high-risk for mortality. Study instruments included the Condensed Memorial Symptom Assessment Scale, the Kansas City Cardiomyopathy Questionnaire QOL subscale, and the number of activities of daily living (ADL) patients had difficulties with. The study included 413 subjects. In generalized linear models which were adjusted for baseline characteristics, the total number of symptoms was significantly associated with worse QOL, as was the presence of each individual symptom, except constipation. Lack of energy demonstrated the strongest negative association with QOL. Similarly, the total number of symptoms was associated with a higher number of ADL difficulties (i.e., worse functional status). The presence of pain, lack of energy and drowsiness was individually associated with more ADL difficulties.
Conclusion: Among patients with advanced HF, a higher number of symptoms and specific individual symptoms were associated with worse QOL and functional status.
背景:生活质量(QOL)和功能状态是晚期心力衰竭(HF)患者的两个关键结果。我们研究了晚期心力衰竭患者的 11 种症状与生活质量和功能状态损害之间的关系:这是对一项多中心、分组随机对照试验(NCT01459744)基线数据的回顾性分析,该试验招募了植入心律转复除颤器的晚期高危心力衰竭患者。研究工具包括浓缩纪念症状评估量表、堪萨斯城心肌病问卷 QOL 子量表以及患者日常生活(ADL)困难的数量。该研究包括 413 名受试者。在根据基线特征进行调整的广义线性模型中,症状总数与患者的 QOL 差异显著相关,除便秘外,每个症状的存在也与 QOL 差异显著相关。乏力与 QOL 的负相关性最强。同样,症状总数也与更多的日常活动障碍有关(即功能状况更差)。疼痛、乏力和嗜睡与更多的日常活动障碍有关联:结论:在晚期高血压患者中,较多的症状和特定的个别症状与较差的 QOL 和功能状态有关。
期刊介绍:
Quality of Life Research is an international, multidisciplinary journal devoted to the rapid communication of original research, theoretical articles and methodological reports related to the field of quality of life, in all the health sciences. The journal also offers editorials, literature, book and software reviews, correspondence and abstracts of conferences.
Quality of life has become a prominent issue in biometry, philosophy, social science, clinical medicine, health services and outcomes research. The journal''s scope reflects the wide application of quality of life assessment and research in the biological and social sciences. All original work is subject to peer review for originality, scientific quality and relevance to a broad readership.
This is an official journal of the International Society of Quality of Life Research.