Asymptomatic Primary Hyperparathyroidism: A Misnomer.

IF 1.8 Q2 OTORHINOLARYNGOLOGY OTO Open Pub Date : 2024-11-04 eCollection Date: 2024-10-01 DOI:10.1002/oto2.70039
Hänel W Eberly, Bao Y Sciscent, F Jeffrey Lorenz, Neerav Goyal, David Goldenberg
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Abstract

Primary hyperparathyroidism (PHPT) is an endocrine disorder marked by elevated secretion of parathyroid hormone (PTH), which results in hypercalcemia and may cause complications in the kidneys and bones. Diagnosing this condition involves ruling out secondary causes and understanding the complexities of the laboratory values associated with PHPT. The disease has become more recognizable to clinicians in an earlier phase thanks to updated screening guidelines. At present, patients can be diagnosed with "classic," "normocalcemic," "normohormonal," or "asymptomatic" PHPT. Many patients are diagnosed through incidental findings of elevated calcium levels or PTH levels during routine blood tests rather than through the presentation of classic symptoms. If asked, patients will invariably harbor subtle or subclinical manifestations despite the absence of overt symptoms. There is debate on whether truly asymptomatic hyperparathyroidism exists.1 We explore the definition and clinical patterns of asymptomatic hyperparathyroidism and propose concise recommendations for recognizing these patients.

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无症状原发性甲状旁腺功能亢进症:名不副实
原发性甲状旁腺功能亢进症(PHPT)是一种以甲状旁腺激素(PTH)分泌增高为特征的内分泌疾病,会导致高钙血症,并可能引起肾脏和骨骼的并发症。诊断这种疾病需要排除继发性病因,并了解与 PHPT 相关的实验室值的复杂性。得益于最新的筛查指南,临床医生已能更早地识别这种疾病。目前,患者可被诊断为 "典型"、"正常钙血症"、"正常激素 "或 "无症状 "的 PHPT。许多患者是在常规血液检查中偶然发现钙水平或 PTH 水平升高而被诊断的,而不是因为出现典型症状。如果被问及,尽管没有明显症状,但患者总会有一些微妙或亚临床表现。1 我们探讨了无症状甲状旁腺功能亢进症的定义和临床模式,并提出了识别这类患者的简明建议。
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来源期刊
OTO Open
OTO Open Medicine-Surgery
CiteScore
2.70
自引率
0.00%
发文量
115
审稿时长
15 weeks
期刊最新文献
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