Role of HOXA10 in pathologies of the endometrium.

IF 6.9 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM Reviews in Endocrine & Metabolic Disorders Pub Date : 2024-11-05 DOI:10.1007/s11154-024-09923-8
Anuradha Mishra, Deepak Modi
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引用次数: 0

Abstract

HOXA10 belongs to the homeobox gene family and is essential for uterine biogenesis, endometrial receptivity, embryo implantation, and stromal cell decidualization. Available evidence suggests that the expression of HOXA10 is dysregulated in different endometrial disorders like endometrial hyperplasia, endometrial cancer, adenomyosis, endometriosis, recurrent implantation failure, and unexplained infertility. The downregulation of HOXA10 occurs by genetic changes in the HOXA10 gene, methylation of the HOXA10 locus, or selected miRNAs. Endocrine disruptors and organic pollutants also cause the reduced expression of HOXA10 in these conditions. In vivo experiments in mouse models and in vitro studies in human cell lines demonstrate that downregulation of HOXA10 leads to endometrial epithelial cell proliferation, failure of stromal cell decidualization, altered expression of genes involved in cell cycle regulation, immunomodulation, and various signaling pathways. These disruptions are speculated to cause infertility associated with the disorders of the endometrium.

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HOXA10 在子宫内膜病变中的作用。
HOXA10 属于同工酶基因家族,对子宫生物发生、子宫内膜接受性、胚胎植入和基质细胞蜕膜化至关重要。现有证据表明,在不同的子宫内膜疾病中,如子宫内膜增生症、子宫内膜癌、子宫腺肌病、子宫内膜异位症、复发性着床失败和原因不明的不孕症等,HOXA10 的表达都会出现失调。HOXA10基因的下调是由HOXA10基因的遗传变化、HOXA10基因座的甲基化或选定的miRNAs引起的。在这些情况下,内分泌干扰物和有机污染物也会导致 HOXA10 的表达减少。小鼠模型的体内实验和人类细胞系的体外研究表明,HOXA10 的下调会导致子宫内膜上皮细胞增殖、基质细胞蜕膜化失败、参与细胞周期调节、免疫调节和各种信号通路的基因表达改变。据推测,这些干扰会导致与子宫内膜紊乱有关的不孕症。
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来源期刊
Reviews in Endocrine & Metabolic Disorders
Reviews in Endocrine & Metabolic Disorders 医学-内分泌学与代谢
CiteScore
14.70
自引率
1.20%
发文量
75
审稿时长
>12 weeks
期刊介绍: Reviews in Endocrine and Metabolic Disorders is an international journal dedicated to the field of endocrinology and metabolism. It aims to provide the latest advancements in this rapidly advancing field to students, clinicians, and researchers. Unlike other journals, each quarterly issue of this review journal focuses on a specific topic and features ten to twelve articles written by world leaders in the field. These articles provide brief overviews of the latest developments, offering insights into both the basic aspects of the disease and its clinical implications. This format allows individuals in all areas of the field, including students, academic clinicians, and practicing clinicians, to understand the disease process and apply their knowledge to their specific areas of interest. The journal also includes selected readings and other essential references to encourage further in-depth exploration of specific topics.
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