Complete genome of single locus sequence typing D1 strain Cutibacterium acnes CN6 isolated from healthy facial skin.

IF 1.9 Q3 GENETICS & HEREDITY BMC genomic data Pub Date : 2024-11-05 DOI:10.1186/s12863-024-01277-z
Ikwhan Kim, Da-Ryung Jung, Ryeong-Hui Kim, Dokyung Lee, YeonGyun Jung, Ji Hoon Ha, Eun Kyung Lee, Jin Mo Kim, Jin Young Kim, Jun-Hwan Jang, Jun-Tae Bae, Yoon Soo Cho, Jae-Ho Shin
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Abstract

Objectives: Cutibacterium acnes is a Gram-positive bacterium commonly found on human skin, particularly in sebaceous areas. While it is typically considered a commensal, specific strain types based on single locus sequence typing (SLST) have been associated with pathogenic conditions or healthy skin. Recently, SLST D1 strains, part of phylotype IA1, have received attention for their potential benefits related to skin health. However, their genetic characteristics remain underexplored. Therefore, the whole genome of C. acnes CN6, an SLST D1 strain isolated from the facial skin of a healthy individual, was sequenced to expand the understanding of SLST D1 strains and identify genomic features that may support skin health.

Data description: The whole genome sequencing of C. acnes CN6 was conducted using MinION reads based on de novo assembly, revealing a single circular complete chromosome. With the length of 2,550,458 bp and G + C content of 60.04%, the genome contains 2,492 genes, including 2,433 CDSs, 9 rRNAs, 46 tRNAs, 4 ncRNAs, and 134 pseudo genes. Previously predicted virulence proteins of C. ances were detected in the genome. Genome comparation with 200 C. acnes strains isolated from healthy facial skin revealed SLST D1 strain-specific genes and a unique variant of the znuC gene in D1 strains.

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从健康面部皮肤中分离出的单位点序列分型 D1 株痤疮切迹杆菌 CN6 的完整基因组。
目的:痤疮棒状杆菌是一种革兰氏阳性细菌,常见于人体皮肤,尤其是皮脂腺部位。虽然它通常被认为是一种共生菌,但基于单基因座序列分型(SLST)的特定菌株类型却与致病条件或健康皮肤有关。最近,属于系统型 IA1 的 SLST D1 菌株因其对皮肤健康的潜在益处而受到关注。然而,它们的遗传特征仍未得到充分探索。因此,我们对从健康人面部皮肤中分离出的 SLST D1 株系--痤疮丙杆菌 CN6 进行了全基因组测序,以扩大对 SLST D1 株系的了解,并确定可能有助于皮肤健康的基因组特征:对痤疮丙酸杆菌 CN6 的全基因组测序是在从头组装的基础上使用 MinION 读数进行的,测序结果显示了一条环状完整染色体。基因组长度为 2,550,458 bp,G + C 含量为 60.04%,包含 2,492 个基因,其中包括 2,433 个 CDS、9 个 rRNA、46 个 tRNA、4 个 ncRNA 和 134 个伪基因。在该基因组中检测到了之前预测的 C. ances 的毒力蛋白。通过与 200 株从健康面部皮肤中分离出来的痤疮丙酸杆菌进行基因组比较,发现了 SLST D1 株系特异性基因和 D1 株系中 znuC 基因的独特变体。
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