Recent advances in and applications of ex vivo drug sensitivity analysis for blood cancers.

IF 2.3 Q2 HEMATOLOGY Blood Research Pub Date : 2024-11-06 DOI:10.1007/s44313-024-00032-8
Haeryung Lee, Nahee Ko, Sujin Namgoong, Seunghyok Ham, Jamin Koo
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Abstract

Blood cancers, including leukemia, multiple myeloma, and lymphoma, pose significant challenges owing to their heterogeneous nature and the limitations of traditional treatments. Precision medicine has emerged as a transformative approach that offers tailored therapeutic strategies based on individual patient profiles. Ex vivo drug sensitivity analysis is central to this advancement, which enables testing of patient-derived cancer cells against a panel of therapeutic agents to predict clinical responses. This review provides a comprehensive overview of the latest advancements in ex vivo drug sensitivity analyses and their application in blood cancers. We discuss the development of more comprehensive drug response metrics and the evaluation of drug combinations to identify synergistic interactions. Additionally, we present evaluation of the advanced therapeutics such as antibody-drug conjugates using ex vivo assays. This review describes the critical role of ex vivo drug sensitivity analyses in advancing precision medicine by examining technological innovations and clinical applications. Ultimately, these innovations are paving the way for more effective and individualized treatments, improving patient outcomes, and establishing new standards for the management of blood cancers.

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血癌体内外药物敏感性分析的最新进展和应用。
血癌(包括白血病、多发性骨髓瘤和淋巴瘤)因其异质性和传统治疗方法的局限性而构成重大挑战。精准医疗已成为一种变革性方法,可根据患者的个体情况提供量身定制的治疗策略。体内外药物敏感性分析是这一进步的核心,它可以针对一组治疗药物对患者衍生的癌细胞进行测试,从而预测临床反应。本综述全面概述了体内外药物敏感性分析的最新进展及其在血癌中的应用。我们讨论了更全面的药物反应指标的开发以及对药物组合的评估,以确定协同作用。此外,我们还介绍了使用体内外试验对抗体-药物共轭物等先进疗法进行评估的情况。本综述通过研究技术创新和临床应用,描述了体内外药物敏感性分析在推进精准医疗方面的关键作用。最终,这些创新技术将为更有效的个体化治疗铺平道路,改善患者的预后,并为血癌的治疗建立新的标准。
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来源期刊
Blood Research
Blood Research HEMATOLOGY-
CiteScore
3.70
自引率
0.00%
发文量
64
期刊最新文献
Correction: Hepatitis B surface antigen reverse seroconversion after hematopoietic stem cell transplantation according to the baseline serological marker levels and vaccination status: a single‑center database analysis. Recent advances in and applications of ex vivo drug sensitivity analysis for blood cancers. PD-1 inhibitors plus chemotherapy for refractory EBV-positive DLBCL: a retrospective analysis. Back to basics: the coagulation pathway. Real-world experience of emicizumab prophylaxis in Korean children with severe hemophilia A without inhibitors.
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