Safety of and chorioretinal circulation during repeated low-level red-light therapy for myopic children.

IF 4.9 2区 医学 Q1 OPHTHALMOLOGY Clinical and Experimental Ophthalmology Pub Date : 2024-11-05 DOI:10.1111/ceo.14462
Zhaoxin Jiang, Shuyu Chen, Renchun Wang, Jin Ma
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Abstract

Background: To evaluate the safety of repeated low-level red-light (RLRL) therapy in children, and the dynamic evolution of choroidal and retinal blood flow.

Methods: This is a single-centre, randomised, single-blind, parallel-group clinical trial. Seventy myopic children were randomly assigned to either the intervention group [receiving RLRL therapy plus single-vision spectacle (SVS)] or the control group (wearing SVS). Participants underwent comprehensive ophthalmic examinations following their first irradiation, 9 months continuous RLRL therapy and stop of treatment. Quantitative analyses of choroidal and retinal microcirculation were analysed via optical coherence tomography angiography.

Results: Over 9 months of treatment, while the RLRL treatment demonstrated significantly less increases in refractive error and axial length compared with the SVS treatment (ps < 0.05), no abnormalities in fundus structure or visual function (mfERG, VEP and microperimetry) were detected (ps > 0.05). A single red-light exposure did not exert a significant influence on choroidal thickness (ps > 0.05). Upon continuous treatment, the RLRL group achieved peak values in these circulations at 9 months (ps < 0.05). Following cessation of exposure, all circulations exhibited a declining trend, reaching similar levels in both groups (ps > 0.05). As the frequency of red-light exposures intensified, there was a consistent surge in these circulations (ps < 0.05).

Conclusions: Nine months of continuous RLRL exposure does not cause toxic side effects on retinal or optic nerve functions, and there is a time-dependent cumulative response in choroidal and retinal circulation.

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近视儿童反复接受低强度红光治疗的安全性和脉络膜循环。
背景:评估儿童反复接受低强度红光治疗的安全性以及脉络膜和视网膜血流的动态演变:评估儿童重复低强度红光(RLRL)治疗的安全性,以及脉络膜和视网膜血流的动态演变:这是一项单中心、随机、单盲、平行组临床试验。70 名近视儿童被随机分配到干预组(接受 RLRL 治疗和单视眼镜 (SVS))或对照组(佩戴 SVS)。参加者在首次接受照射、连续接受 RLRL 治疗 9 个月和停止治疗后接受了全面的眼科检查。通过光学相干断层血管造影术对脉络膜和视网膜微循环进行了定量分析:在 9 个月的治疗过程中,RLRL 治疗与 SVS 治疗相比,屈光不正和轴长的增加明显较少(PS 0.05)。单次红光照射对脉络膜厚度的影响不大(ps > 0.05)。持续治疗后,RLRL 组在 9 个月时达到了这些循环的峰值(ps 0.05)。随着红光照射频率的增加,这些环路的数值也在持续飙升(ps 结论:红光照射对视网膜厚度有显著影响(ps > 0.05):连续接触红光照射 9 个月不会对视网膜或视神经功能产生毒副作用,脉络膜和视网膜循环的累积反应与时间有关。
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来源期刊
CiteScore
7.60
自引率
12.50%
发文量
150
审稿时长
4-8 weeks
期刊介绍: Clinical & Experimental Ophthalmology is the official journal of The Royal Australian and New Zealand College of Ophthalmologists. The journal publishes peer-reviewed original research and reviews dealing with all aspects of clinical practice and research which are international in scope and application. CEO recognises the importance of collaborative research and welcomes papers that have a direct influence on ophthalmic practice but are not unique to ophthalmology.
期刊最新文献
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