High-grade squamous intraepithelial lesions and adenocarcinoma in situ with a negative HPV cervical screening test. The role of HPV-ISH testing: A retrospective review.

IF 1.4 4区 医学 Q3 OBSTETRICS & GYNECOLOGY Australian & New Zealand Journal of Obstetrics & Gynaecology Pub Date : 2024-11-05 DOI:10.1111/ajo.13892
Jonathan Sandeford, Unine Herbst, Trina Lum, Lyndal Anderson, Selvan Pather
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Abstract

Australia has transitioned to primary Human Papillomavirus (HPV) screening; however, high-risk HPV (hrHPV)-negative high-grade squamous intraepithelial lesions and adenocarcinoma in situ have been reported. HPV in situ hybridisation (ISH) testing has been proposed to reclassify these cases. This study identified hrHPV-negative lesions and assessed HPV-ISH. A total of 89 of 1468 patients (6.06%) had hrHPV-negative lesions, and HPV-ISH revealed five (5.75%) reclassified positive cases. No demographical differences were found between groups. Current population-level screening is effective. HPV-ISH was not effective for reclassification. This small, significant population requires further study to assess the phenomenon and augment detection given the implications of misidentification.

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HPV宫颈筛查阴性的高级别鳞状上皮内病变和原位腺癌。HPV-ISH检测的作用:回顾性研究。
澳大利亚已过渡到初级人类乳头瘤病毒(HPV)筛查,但也有高危 HPV(hrHPV)阴性高级别鳞状上皮内病变和原位腺癌的报道。有人建议通过 HPV 原位杂交(ISH)检测对这些病例进行重新分类。本研究确定了 hrHPV 阴性病变,并对 HPV-ISH 进行了评估。在 1468 例患者中,共有 89 例(6.06%)为 hrHPV 阴性病变,HPV-ISH 发现了 5 例(5.75%)重新分类的阳性病例。各组之间未发现人口统计学差异。目前的人群筛查是有效的。HPV-ISH对重新分类无效。考虑到误诊的影响,需要对这一小部分重要人群进行进一步研究,以评估这一现象并加强检测。
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来源期刊
CiteScore
3.40
自引率
11.80%
发文量
165
审稿时长
4-8 weeks
期刊介绍: The Australian and New Zealand Journal of Obstetrics and Gynaecology (ANZJOG) is an editorially independent publication owned by the Royal Australian and New Zealand College of Obstetricians and Gynaecologists (RANZCOG) and the RANZCOG Research foundation. ANZJOG aims to provide a medium for the publication of original contributions to clinical practice and/or research in all fields of obstetrics and gynaecology and related disciplines. Articles are peer reviewed by clinicians or researchers expert in the field of the submitted work. From time to time the journal will also publish printed abstracts from the RANZCOG Annual Scientific Meeting and meetings of relevant special interest groups, where the accepted abstracts have undergone the journals peer review acceptance process.
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