The triglyceride-glucose index as an indicator of latent atherogenicity of the plasma lipid profile in healthy men with normolipidaemia.

Anastasiya M Kaneva, Natalya N Potolitsyna, Evgeny R Bojko
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Abstract

Objectives: The triglyceride-glucose (TyG) index is a novel diagnostic marker for various metabolic and cardiovascular diseases. However, little is known about the association of the TyG index with plasma atherogenicity, especially with its latent forms. The aim of this study was to assess the potential of the use of the TyG index as a marker of atherogenic risk.

Methods: A total of 202 men with normolipidaemia, aged 20-60 years, were enrolled in this study. Fasting biochemical parameters were measured. The TyG index was calculated as ln[triglyceride(mg/dL)×glucose(mg/dL)]/2. The diagnostic ability of the TyG index for detecting atherogenic risk was tested by receiver operating characteristic (ROC) curve analysis.

Results: A substantial portion of normolipidaemic men had deviations from the reference values for the indices calculated using apolipoproteins. Unfavorable values for the apolipoprotein (apo) B/apoA-I ratio, low-density lipoprotein cholesterol/apoB (LDL-C/apoB) ratio, and the atherogenic index (ATH index) were observed in 32.7%, 31.7%, and 14.4% of men, respectively. The results of ROC curve analysis showed that the TyG index had good diagnostic ability for identifying unfavorable apolipoprotein indices in normolipidaemic men.

Conclusions: Thus, the TyG index can be a valuable additional marker for assessing latent atherogenic risk; it can provide useful information for the diagnosis and treatment of early atherosclerosis.

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甘油三酯-葡萄糖指数作为血脂正常的健康男性血浆脂质谱潜在致动脉粥样硬化性的指标。
目的:甘油三酯-葡萄糖(TyG)指数是各种代谢和心血管疾病的新型诊断指标。然而,人们对 TyG 指数与血浆致动脉粥样硬化性,尤其是其潜在形式的关联知之甚少。本研究旨在评估使用 TyG 指数作为动脉粥样硬化风险标志物的潜力:方法:本研究共招募了 202 名血脂正常的男性,他们的年龄在 20-60 岁之间。测量了空腹生化指标。TyG指数的计算公式为ln[甘油三酯(毫克/分升)×葡萄糖(毫克/分升)]/2。通过接收器操作特征曲线(ROC)分析检验了TyG指数对检测动脉粥样硬化风险的诊断能力:相当一部分血脂正常的男性在使用脂蛋白计算指数时偏离了参考值。分别有32.7%、31.7%和14.4%的男性观察到载脂蛋白(apo)B/apoA-I比率、低密度脂蛋白胆固醇/apoB(LDL-C/apoB)比率和致动脉粥样硬化指数(ATH指数)的不利值。ROC曲线分析结果表明,TyG指数对鉴别血脂正常男性的不良载脂蛋白指数具有良好的诊断能力:因此,TyG指数可以作为评估潜在致动脉粥样硬化风险的一个有价值的附加标记物;它可以为早期动脉粥样硬化的诊断和治疗提供有用的信息。
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