Effectiveness of long-term bimekizumab treatment and predictive factors for responders in moderate-to-severe psoriasis: A 52-week real-world study.

Teppei Hagino, Hidehisa Saeki, Eita Fujimoto, Naoko Kanda
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Abstract

Psoriasis is a chronic, inflammatory skin disease in which the interleukin (IL)-23/IL-17 axis plays a central role. Bimekizumab is a novel antibody that targets both IL-17A and IL-17F. This retrospective study aimed to assess the long-term effectiveness and safety of 52-week treatment with bimekizumab, and to identify predictive factors for short- (16 weeks) and long-term (52 weeks) responders (i.e., achievers of a Psoriasis Area and Severity Index (PASI) score of 100) to bimekizumab in Japanese patients with psoriasis. The study was conducted on 56 Japanese patients (aged ≥ 15 years) with moderate-to-severe psoriasis treated with bimekizumab from May 2022 to March 2024. The therapeutic effectiveness was evaluated by the transition of PASI scores during treatment. Baseline characteristics and clinical and laboratory indexes were compared between responders and poor responders. Treatment-emergent adverse events (TEAEs) were recorded to assess the safety of the treatment. At week 52, the achievement of PASI 100, static Physician's Global Assessment 0/1, and the Dermatology Life Quality Index 0/1 were 72.4%, 94.7%, and 93.3%, respectively. Short-term responders showed lower baseline values of neutrophil-to-lymphocyte ratio, monocyte-to-lymphocyte ratio (MLR), and systemic inflammatory response index compared to poor responders. Long-term responders showed younger age and lower MLR compared to poor responders. TEAEs were mild or moderate, without serious adverse events. Long-term treatment with bimekizumab is effective and safe for psoriasis patients. Lower MLR and younger age might predict long-term response to treatment with bimekizumab, aiding in personalized treatment strategies.

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中度至重度银屑病患者长期使用双美珠单抗治疗的疗效及应答者的预测因素:一项为期 52 周的真实世界研究。
银屑病是一种慢性炎症性皮肤病,白细胞介素(IL)-23/IL-17 轴在其中起着核心作用。Bimekizumab是一种新型抗体,可同时靶向IL-17A和IL-17F。这项回顾性研究旨在评估使用比美单抗进行52周治疗的长期有效性和安全性,并确定日本银屑病患者对比美单抗短期(16周)和长期(52周)应答者(即银屑病面积和严重程度指数(PASI)达到100分者)的预测因素。该研究在 2022 年 5 月至 2024 年 3 月期间对 56 名日本中重度银屑病患者(年龄≥ 15 岁)进行了比美单抗治疗。疗效通过治疗期间 PASI 评分的变化进行评估。比较了应答者和应答不佳者的基线特征、临床和实验室指标。记录治疗突发不良事件(TEAE)以评估治疗的安全性。第52周时,PASI 100、静态医生总体评估0/1和皮肤科生活质量指数0/1的达标率分别为72.4%、94.7%和93.3%。与不良反应者相比,短期反应者的中性粒细胞与淋巴细胞比率、单核细胞与淋巴细胞比率(MLR)和全身炎症反应指数的基线值较低。与反应差者相比,长期反应者的年龄更小,MLR更低。TEAE为轻度或中度,无严重不良反应。对银屑病患者来说,使用比美珠单抗进行长期治疗既有效又安全。较低的MLR和较年轻的年龄可能预示着对bimekizumab治疗的长期反应,有助于制定个性化治疗策略。
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